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  • Nitrofurantoin Raw Material Nitrofurantoin Powder

    • Nitrofurantoin Raw Material Nitrofurantoin Powder
    • Nitrofurantoin Raw Material Nitrofurantoin Powder
    • Nitrofurantoin Raw Material Nitrofurantoin Powder storehouse
    • Nitrofurantoin Raw Material Nitrofurantoin Powder quality testing
    • Nitrofurantoin Raw Material Nitrofurantoin Powder quality testing
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    Product Overview:

    Manufacturer Supply Purity 99% Nitrofurantoin Raw Material, High Quality Nitrofurantoin Raw Powder Factory Supply Nitrofurantoin Powder Raw Manufacturer of Supply Nitrofurantoin Powder Nitrofurantoin Raw Materials is a synthetic antimicrobial agent with a wide antibacterial spectrum, having antibacterial effects on most Gram-positive and negative bacteria.

    Nitrofurantoin Raw Material Nitrofurantoin Powder Attributes

    Nitrofurantoin Raw Materials Powder CAS 67-20-9

    CAS:67-20-9

    MF: C8H6N4O5

    Nitrofurantoinl Raw Materials

    MW: 238.16

    EINECS:200-646-5

    Specification: 99% min Nitrofurantoin HCl Powder

    Sample: Nitrofurantoin HCl Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Nitrofurantoin Raw Material Nitrofurantoin Powder Details

    Nitrofurantoin Powder Usage and Synthesis.

    Hydrochloric acid and purified water were added into a reverse osmosis membrane reaction device installed, warmed up to 60°C~70°C, added diethyl 5-nitrofurfural, maintained at 80°C~85°C hydrolysis was complete, added the catalyst and the appropriate amount of sodium chloride solids, and then added aminoacetic acid urea which was preheated to 60°C~70°C, pressurised, maintained at 90°C~95°C refluxing, kept warm for 40min~60min, and the The reaction product was washed with purified water to pH 6.0~8.0, shake out the dry material, and wash the obtained furantoin with flowing purified water at 90°C~95°C for a certain time to obtain the finished furantoin.

    Nitrofurantoin Powder

    Uses and functions of Nitrofurantoin.

    It is used for acute simple lower urinary tract infections caused by Escherichia coli, Enterococcus, Staphylococcus, Klebsiella, Enterobacter, etc.; it is also used for the prevention of urinary tract infections.

    Nitrofurantoin is an excellent antibacterial drug, oral absorption is rapid and complete, excretion is also faster, in the urine excretion of up to 40-50%, commonly used in the treatment of a variety of sensitive bacteria caused by urinary tract infections, to E. coli caused by acute urinary tract infections, the efficacy of better.

    Nitrofurantoinl Raw Materials

    Pharmacological Effects of Nitrofurantoin Raw.

    It has a wide antibacterial spectrum, and its mechanism of action is to interfere with bacterial oxidoreductase and block the normal metabolism of bacteria.

    It has good antibacterial effect on staphylococcus, enterococcus, Escherichia coli, Neisseria (gonococcus, etc.), bacillus subtilis, shigella, salmonella, etc. It has weak effect on Aspergillus, Klebsiella, Enterobacter, Serratia and so on; and it is ineffective against Pseudomonas aeruginosa.

    Generally speaking, microorganisms are not easy to resist this product, and it can still be effective after stopping the drug and re-administering it. However, drug-resistant strains have increased in recent years. If necessary, it can be combined with other drugs (such as TMP) to improve the efficacy.

    1. The microcrystalline form of this product is rapidly and completely absorbed in the small intestine, while the absorption of the large crystalline form is slower. Taking with food can increase the bioavailability of both crystalline types. The concentration of the drug in the serum is very low, and the concentration in the urine is high.

    2. Nitrofurantoin can cross the placental and blood-cerebrospinal fluid barriers. The serum protein binding rate is 60%. Blood elimination half-life (t1/2) is 0.31 hours. Glomerular filtration is the main route of excretion, a small amount of secretion and reabsorption from the renal tubules. 30%-40% rapidly excreted in the urine in its original form, the excretion of large crystalline type is slower. It is also excreted in the bile and cleared by dialysis.

    Nitrofurantoinl CAS 67-20-9

    Production method of Bulk Nitrofurantoin Powder.

    Aminourea is produced by the condensation of hydrazine hydrate with urea, and then condensed with acetone to produce acetone-acetonitrile urea. It is then cyclised with ethyl chloroacetate to produce acetone acetonide urea, which is hydrolysed and condensed with 5-nitrofurfural diacetate to produce furantoin.

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