Pharmaceutical
Human APIs Powder
- Respiratory Drugs Raw Material
- Antiviral Antibacterial
- Antipyretic Analgesics
- Antihistamine Drugs
- Antineoplastic
- Cosmetic Raw Material
OEM & ODM
Veterinary raw materials
Phone: 86-29-89601602
E-mail: sales21@interlgroup.com
Add: Fengcheng 2nd Road, Weiyang District, Xi'an, Shaanxi, China
Pharmaceutical Bulk P-Aminobenzoic acid Powder
Product Overview:
4-Aminobenzoic acid is one of the most important aromatic amino acids, is an important part of the body's cell growth and division of substances necessary for the metabolism of life has an irreplaceable role in the Chemicalbook, in yeast, liver, bran, malt, the content of which is very high. 4-Aminobenzoic acid can alleviate the anaemia caused by the lack of red blood cells, viral anaemia, stomatitis diarrhoea and anaemia during pregnancy. anaemia in pregnancy.
Pharmaceutical Bulk P-Aminobenzoic acid Powder Attributes
Pharmaceutical Bulk P-Aminobenzoic acid Powder
CAS:150-13-0
MF: C7H7NO2
MW:137.14
EINECS:205-753-0
Specification: 99% min P-Aminobenzoic acid Powder
Sample: P-Aminobenzoic acid Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: White Powder
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Pharmaceutical Bulk P-Aminobenzoic acid Powder Details
P-Aminobenzoic acid Powder Usage and Synthesis.
P-aminobenzoic acid is also an important fine chemical material, in medicine, is the synthesis of blood tonic - folic acid, pro-coagulant - p-carboxybenzylamine key intermediates, but also used in the manufacture of drugs for the treatment of rickets, rheumatism, arthritis, tuberculosis.
In the cosmetic industry, it is an important sunscreen agent, hair growth agent intermediate; in the organic chemical industry, it is used to prepare a variety of ester products, can be used as a resin modifier, and can also be used for the synthesis of reactive dyes, azodyes, special intermediates.
Uses and functions of P-Aminobenzoic acid Powder.
aminobenzoic acid can be used as dyes and pharmaceutical intermediates. It is used in the production of reactive red M-80, M-10B, reactive red violet X-2R and other dyes, as well as the production of p-carboxybenzylamine from cyanobenzoic acid.
P-aminobenzoic acid can be used as a sunscreen agent, its derivatives of p-dimethylcarbamic acid octyl ester, is an excellent sunscreen agent, trade name PadimateO. Widely distributed in nature as a B complex factor. Baker yeast contains 5 to 6 ppm, brewer yeast from 10 to 100 ppm. Occurs free and in ester form.
Pharmacological Effects of P-Aminobenzoic acid.
p-Aminobenzoic acid was prepared as follows: 38.0g of p-nitrobenzoic acid, 200mL of water, 20mL of tetrahydrofuran, 0.4g of sodium dodecyl sulfonate, and 1.9g of Raney nickel were added to the autoclave, nitrogen was replaced three times, hydrogen was filled in, the pressure was adjusted to 0.9±0.1MPa, and the temperature was adjusted to 100±2℃, and the reaction was held at a constant pressure for 4h until complete.
At the end of the reaction, the catalyst was recovered by filtration, static layering, the aqueous layer was directly applied, the tetrahydrofuran layer was distilled and recovered and applied, and then 1.5g of activated carbon was added to the mother liquor of 4-aminobenzoic acid, and under the protection of nitrogen, the heated reflux decolourisation was carried out for 20min, filtration was carried out, the mother liquor was cooled to crystallize, filtration was carried out, and the mother liquor was dried at 80~85℃ under vacuum to obtain 30.3g of p-aminobenzoic acid in the yield of 97.2%, melting point of 187.1±0.0MPa. The melting point was 187.1~187.6℃ and the content was 100.2% (permanent stop titration method).
Production method of Bulk P-Aminobenzoic acidm Powder.
Add water, sodium chloride, hydrochloric acid in turn in the reaction pot.
Start stirring and raise the temperature to 50-60 ° C, add 9/10 amount of iron powder, continue to raise the temperature to 98-102 ° C, holding 1h, stop heating, slowly add p-nitrobenzoic acid at 95 ° C, about 1-1.5h added, add iron powder, holding at 98-102 ° C for 1h, cooling to 80 ° C, add 30% of the liquid alkali adjustment pH = 8.5-9, pressure filtration, wash with a small amount of water, filtrate and a small amount of washings merged. A small amount of washings combined, pressed into the acid precipitation pot, cooled to 30-34 ℃, add insurance powder decolourisation, filtration. Add acid to the filtrate to adjust pH=3.5-4, continue to cool to below 10℃, shake off the water, dry to get the finished product.
Yield 84-88%. (2) from p-nitrobenzoic acid by catalytic hydrogenation and obtained in 1000ml beaker add industrial p-nitrobenzoic acid and water, under stirring with 22% sodium hydroxide to adjust pH = 6-7, then add Ruan Ni nickel, under stirring the material is pumped into the swinging autoclave, respectively, hydrogen, nitrogen, each replaced twice, and then filled with pressure to 3.43MPa, under the pressure of 3.43-2.54MPa, temperature The reaction was carried out at a pressure of 3.43-2.54MPa and a temperature of 134-140℃ for about 5h, until the hydrogen pressure did not drop as the end point.
After the end of the reaction, filter and dry to get p-aminobenzoic acid. The yield is more than 80%.