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  • Pharmaceutical Bulk Ribavirin Powder

    • Pharmaceutical Bulk Ribavirin Powder
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    Product Overview:

    Ribavirin is a guanosine, hypoxanthine nucleoside analogue, is a broad-spectrum antiviral drugs, a variety of DNA and RNA viruses have good inhibition. It has the characteristics of multiple sites of action, not easy to produce drug resistance, high efficacy, low toxicity, small side effects, etc., and is now used in the treatment of a variety of viruses. It is used in the treatment of hepatitis C virus, respiratory syncytial virus and Lassa fever virus infection.

    Pharmaceutical Bulk Ribavirin Powder Attributes

    Pharmaceutical Bulk Ribavirin Powder

    CAS:36791-04-5

    MF: C8H12N4O5

    Bulk Ribavirin

    MW:244.21 

    EINECS:636-825-3

    Specification: 99% min Ribavirin Powder

    Sample: Ribavirin Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceutical Bulk Ribavirin Powder Details

    Ribavirin Powder Usage and Synthesis.

    Ribavirin has significant inhibitory effects on a variety of RNA and DNA viruses, and also has strong inhibitory effects on HIV. The mechanism of antiviral action of ribavirin has not yet been fully determined, and its mechanism of action varies for different viruses.

    Ribavirin (RBV, viral azole) is a synthetic broad-spectrum antiviral drug, has been used for many years for the treatment of viral infections of choice, because of its role in the precise, inexpensive, clinically commonly used in infants, young children and adults, influenza, diarrhoea, and with interferon for the combination of various types of hepatitis treatment.

    Ribavirin Powder

    Uses and functions of Ribavirin.

    Ribavirin has a wide range of uses in medicine and is clinically effective against hepatitis A, influenza, various herpes, as well as against respiratory syncytial virus, human immunodeficiency virus, infections with epidemic haemorrhagic fever virus, and skin diseases.

    Ribavirin is the only effective treatment for respiratory syncytial virus and is the drug of choice for the treatment of epidemic haemorrhagic fever.

    In recent years its use in hepatitis B and C has also shown better results and in India the drug is approved for the treatment of acute hepatitis, respiratory tract infections and herpes simplex infections.

    In the UK, Switzerland, Italy, the United States and other countries it is approved as a preventive drug for AIDS, and in 2003 it was used in Canada and Hong Kong as a pre-treatment drug for SARS virus.

    Broad-spectrum antiviral for influenza (caused by influenza viruses A and B), adenovirus pneumonia, hepatitis A, herpes, measles, etc., with preventive and curative effects; effective against epidemic haemorrhagic fever.

    It is especially effective in early stage patients.

    Oral can cause diarrhoea, no other obvious toxicity, but there can be leukopenia, overdose inhibition of haemoglobin and erythrocyte maturation and lead to reversible anaemia.

    There are reports of teratogenicity and embryotoxicity in animal experiments, and it is contraindicated in pregnant women.

    Bulk Ribavirin

    Pharmacological Effects of Ribavirin.

    1, ribavirin is phosphorylated in erythrocytes to generate triazole nucleoside monophosphate, diphosphate and triphosphate.

    Among them, triazole nucleoside monophosphate is a strong inhibitor of inosine monophosphate dehydrogenase, which can inhibit cellular guanosine monophosphate synthesis, reduce cellular guanosine monophosphate triphosphorylation, and block the synthesis of viral nucleic acids.

    2, Triazole nucleoside triphosphate inhibits influenza virus RNA polymerase and interferes with virus replication.

    3, Triazole nucleoside triphosphate inhibits the synthesis and transcriptase of viral mRNA 5'end, thus inhibiting DNA and RNA synthesis.

    Inhibits a variety of viruses (including DNA-type viruses and RNA-type viruses). It is effective against influenza, adenovirus pneumonia, hepatitis A, herpes, measles, etc. It is also effective against epidemic haemorrhagic fever.

    4, mainly through the urine to the original form of excretion, but also a small amount of deglycosylated triazole nucleoside metabolites, a small amount of fecal excretion.

    Bulk Ribavirin Powder

    Production method of Bulk Ribavirin Powder.

    Nucleoside or nucleotide as raw material first guanosine and guanosine acid in the glacial acetic acid and acetic anhydride under the action of hydrolysis, the generation of ribulose-1-phosphate, and then in the bis - p-nitrophenol catalysed, and the reaction with the triazide condensation amide condensate, ammonia solution is obtained.

    Guanosine (or guanosine acid) [ethanoic anhydride, glacial acetic acid] → [hydrolysis] ribose-1-phosphate [bis-(p-nitrophenol)-phosphate] → [triazide carboxamide] condensate [ammonia] → triazole nucleoside enzyme synthesis method firstly, guanosine and guanosinic acid will be hydrolysed under the action of pyrimidine nucleoside phosphorylase, generating ribose-1-phosphate, and then reacted with triazide condensate amide under the action of purine nucleoside phosphorylase to produce directly Triazole nucleoside.

    Guanosine (or guanosine acid) [pyrimidine nucleoside phosphorylase] → ribulose-1-phosphate [purine nucleoside phosphorylase] → triazole nucleoside.

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