Amygdalin Raw Materials Powder CAS 29883-15-6

CAS:29883-15-6

MF: C20H27NO11

MW: 457.43

EINECS:249-925-3

Specification​: 99% min Amygdalin Powder

Sample: Amygdalin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Amygdalin Powder Usage and Synthesis.

Amygdalin (from the Greek word for "flat peach"), also known as bitter amygdalin, is a toxic cyanogenic glycoside found in many plants, but most notably in the seeds of apricots, bitter almonds, apples, peaches and prunes. Its a glycoside isolated from the seeds of the lentil in 1803 by Pierre-Jean Lobique & A. F. Boutron-Charlard. Liebig & Wille studied this substance in 1830. Bitter amygdalin is also found in other Plums, including apricots and black cherries, and in the leaves, fruits, and kernels of loquats. Ernst T. Krebs named this substance "Vitamin B17" and suggested that it could treat cancer, but subsequent studies have shown that it does not have these effects. The scientific community does not consider amygdalin to be a vitamin either, as it does not fulfil the definition of a vitamin.

Uses and functions of Amygdalin.

Almonds contain 3% amygdalin, the enzyme decomposition to form hydrocyanic acid, hydrocyanic acid is toxic, but a small amount of the respiratory centre has a sedative effect, so the literature has documented the effect of antitussive and asthmatic, and kill typhoid fever bacillus and other bacterial effects. In recent years, scientific research at home and abroad has proved that hydrocyanic acid has anti-cancer effect, which is really a good product for human health.

As a glucoside-containing cyanide, it can be used as a substrate for the identification, differentiation and characterisation of such enzymes as maltase, amygdalinase and β-glucosidase.

Pharmacological Effects of  Amygdalin.

1. Cardiovascular effects of amygdalin

2. Effects of amygdalin on digestive system

Anti-gastric ulcer: by establishing a mouse bound-frozen stress gastric ulcer model, a rat acetic acid cauterised ulcer model, and a rat pylorus ligated gastric ulcer model, in order to observe the effects of bitter almond glycosides on experimental gastric ulcers.

3. The effect of bitter amygdalin on urinary system

4. the effect of amygdalin on immune system

(1) Immunomodulation: subcutaneous injection of Freund's complete adjuvant antigen was used to establish a rat model of chronic immuno-atrophic gastritis; intradermal injection of Freund's complete adjuvant into the foot and metatarsal was used to cause adjuvant arthritis in rats; the carbon granule contouring assay was used to determine the contouring index (K) and the phagocytic index (A) of mice, and the effects of picricarpene glycosides on adjuvant inflammation and carbon granule contouring of mice were observed, in order to reveal their effects. The effects of bitter amygdalin on adjuvant inflammation in rats and carbon granule contouring in mice were observed to reveal its immunomodulatory effects. The results showed that the administration of bitter amygdalin 20 mg/kg by gavage for 6 consecutive weeks had an effect on chronic immuno-atrophic gastritis in rats, with a decrease in the total acidity of gastric juice and an increase in the activity of pepsin in each dose group; the concentration of 10 and 20 mg /kg for 1 week significantly inhibited the degree of foot-plantar swelling after adjuvant inflammation in rats; and a concentration of 40 mg /kg for 1 week significantly increased the K and A of the experiments.

2) Immunosuppression

5. Anti-tumour effect of bitter amygdalin

6. Effects of amygdalin on respiratory system

(1) Cough suppressant effect: Using enzyme digestion method to stabilise the bronchial smooth muscle cells BSMC, passaged in DMEM-F12 medium containing 10% fetal bovine serum, treated with different concentrations of amygdalin, the cells began to show inhibition after 24 h. The inhibition was concentration-dependent within the range of 0.022～0.704 g/L, and it was the strongest inhibition when the concentration was 0.704 mmol/L, which could be up to 50%. The inhibition was concentration-dependent in the range of 0.022～0.704 g /L, with the strongest inhibition at the concentration of 0.704 mmol/L, which could reach 50%.

(2) Antiasthmatic effect: through the model of guinea pig asthma caused by acetylcholine and histamine phosphate, and the model of guinea pig asthma caused by ovalbumin to compare the antiasthmatic effect of bitter almond, Platycodon grandiflorus and the combination of the two, the results show that bitter almond, Platycodon grandiflorus and the combination of the two can significantly prolong the latent period of guinea pig asthma caused by acetylcholine and histamine phosphate, and significantly reduce the number of inflammatory cells in the model of guinea pig asthma caused by ovalbumin.

The results showed that amygdalin promoted the proliferation of preterm rat AECII cells in a dose-dependent manner from 50 to 200 mol/L, and its effect was strongest when the concentration was 200 mol/L, but was inhibitory when it was 400 mol/L, which suggested that amygdalin in the appropriate dosage form is expected to be an effective drug for the prevention and treatment of bronchopulmonary dysplasia.

7. Other effects of amygdalin

1) Analgesic effect

(2) Anti-inflammatory effect: 1, 10, 100, 1000 mg / L concentration of bitter amygdalin treatment of mice

(3) Retardation of intervertebral disc degeneration.

Production method of Amygdalin Raw Powder.

1. Water extraction method

With almond as raw material, the extraction process was as follows: extraction time 20 min, solid-liquid ratio 1:10, soaking time 30 min, extraction twice, the extraction rate of bitter amygdalin was close to 3.2% in this method. With raw peach kernel as raw material, the content of amygdalin in the extract was 2 times of that in cold water, and the water, extraction time and number of times of extraction had no significant effect on the extraction rate of amygdalin, suggesting that it is more appropriate to use hot water for direct extraction of amygdalin in raw peach kernel. The results showed that the extraction rate of bitter amygdalin was 95.77% when using distilled bitter amygdalin water method, which was significantly higher than that of reflux decoction method (55.61%) and alcoholic extraction of bitter amygdalin method (64.88%).

2. Alcohol extraction method

Using apricot pollen as raw material, the bitter amygdalin was extracted with anhydrous ethanol at a solid-liquid ratio of 1:7, ultrasonication for 20 min for 12 h. The extraction rate of bitter amygdalin in this method was 6.1%. Bitter almond as raw material, using bitter amygdalin easily soluble in hot ethanol, slightly soluble in cold ethanol nature of the extraction of bitter amygdalin, the results show that, plus 6 times 95% ethanol extraction for 1h, a total of 2 times, the bitter amygdalin crude, crude with anhydrous ethanol with a solid-liquid ratio of 1:30 recrystallisation 3 times for purification, this method of bitter amygdalin extraction rate of 92.47%, the transfer rate of 45.92%.1. aqueous extraction method

With almond as raw material, the extraction process is as follows: extraction time 20 min, solid-liquid ratio 1:10, soaking time 30 min, extraction twice, the extraction rate of bitter amygdalin in this method is close to 3.2%. With raw peach kernel as raw material, the content of amygdalin in the extract was 2 times of that in cold water, and the water, extraction time and number of times of extraction had no significant effect on the extraction rate of amygdalin, suggesting that it is more appropriate to use hot water for direct extraction of amygdalin in raw peach kernel. The results showed that the extraction rate of bitter amygdalin was 95.77% when using distilled bitter amygdalin water method, which was significantly higher than that of reflux decoction method (55.61%) and alcoholic extraction of bitter amygdalin method (64.88%).