High Purity Bulk Curcumin Powder

CAS:458-37-7

MF: C21H20O6

MW: 368.38

EINECS:207-280-5

Specification​: 99% min Curcumin Powder

Sample: Curcumin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: orange Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Curcumin Powder Usage and Synthesis.

Kuttan, an Indian scholar, first proposed the anticancer effect of curcumin in 1985. In recent years, curcumin has been found to have an inhibitory effect mechanism on the production, proliferation and metastasis of many kinds of tumour cells. The National Cancer Institute of the United States listed it as the 3rd generation of tumour therapeutic agent. When paired with mitomycin C, it reduces the dosage of mitomycin C. At the same time, it can reduce the nephrotoxicity and myelosuppression produced by the use of mitomycin C alone, and it can improve the effect of mitomycin C in the treatment of breast cancer.

Curcumin has a protective effect in vitro and in vivo against various toxic substances such as carbon tetrachloride, aflatoxin B1, acetaminophen, cyclophosphamide-induced hepatic damage, and significantly reduces alkaline phosphatase and r-glutamyl transpeptidase (r-GT) activities in animals with alcoholic liver injury (ALI), preventing the occurrence of experimental fatty liver.

Uses and functions of Curcumin.

Edible yellow colouring. It has been used in China for a long time for dried radish and curry powder. In Japan, it is used in pickles, ham, sausages and candied apples, pineapples and chestnuts.

Acid-base indicator, pH 7.8 (yellow) to 9.2 (reddish brown). Colour developing reaction to measure beryllium, zirconium and magnesium, borates and reagents.

A natural phenolic substance, anti-tumour and anti-inflammatory substance with antioxidant properties, induces apoptosis in cancer cells

Manufacture of turmeric test paper, pH 8-9; measurement of boron

Pure natural food colouring agent with strong colouring power, good heat resistance and good light resistance characteristics.

Chemical Properties of Curcumin.

Orange-yellow crystalline powder. With special odour. Melting point 179～182℃. Insoluble in water and ether, soluble in ethanol, glacial acetic acid, propylene glycol. Reddish brown under alkaline condition, light yellow under acidic condition. Forms colour precipitate with magnesium hydroxide, yellowish red. Forms chelates with metal ions, especially iron ions, resulting in discolouration.

About 5mg/kg of iron ions start to affect the pigment, and above 10mg/kg it becomes reddish brown and the colouring ability is reduced, so it is necessary to use appropriate containers. It is better to use it together with chelating agent sodium hexametaphosphate and acid sodium pyrophosphate. Light resistance, poor resistance to iron ions, heat resistance is better. Strong adhesion (especially to proteins). There are two active phenol structures in each molecular structure, so it has a certain antioxidant capacity.

Production method of  Bulk Curcumin Powder.

(1) water as a solvent extraction. 70-80 ℃ first 8 times the amount of 1% sodium hydroxide solution leaching 0.175-.036mm turmeric powder 60-75min, filtered filter residue and then leaching twice, the amount of solvent and time can be reduced in order of discretion; combined with the three times the filtrate, add the amount of 0.8% sodium bisulphite solution, after concentration and adjust the PH with hydrochloric acid for 3-4; static stratification and abandon the upper layer Clear liquid, the lower precipitate by filtration of semi-solid curcumin, turmeric oil and turmeric resin mixture; at 70 ℃ in 70% ethanol to dissolve the mixture, while hot and filtered to remove insoluble in ethanol turmeric resin, filtrate and then use petroleum ether extraction to separate the turmeric oil, petroleum ether phase by distillation under reduced pressure recovery of petroleum ether turmeric oil, extracted residual ethanol phase by distillation under reduced pressure curcumin, yields of up to 0.5 percent - 1.5 percent. 1.5%.

(2) Organic solvent extraction. Curcumin can be dissolved in ethanol, ether, acetone or dichloromethane and other solvents, can choose one from 0.16-0.32mm turmeric powder leaching curcumin and turmeric oil, after separation and concentration of petroleum ether extraction separation of curcumin oil, extracted by decompression distillation of the residual phase of curcumin, the yield is generally 0.55%-1.5%.

(3) Step-by-step extraction. At 100-105 ℃ turmeric powder steam distillation 4-6h, get turmeric oil, at 80 ℃ with 1% sodium hydroxide solution soaked slag 25min; filtration, filtrate with hydrochloric acid neutralisation acidification, and then filtered to get the curcumin crude, refined to get the finished product!