Berberine Raw Materials Powder 2086-83-1

CAS:2086-83-1

MF: C20H18NO4

MW:336.37

EINECS:218-229-1

Specification: 99% min Berberine Powder

Sample: Berberine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White to yellow crystals

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Berberine Powder Usage and Synthesis.

The antihypertensive effect of safranin is very good, most of the elderly patients with hypertension after taking the drug, blood pressure can be reduced to the normal range; safranin also has the effect of lowering blood glucose, urinary glucose; safranin to improve the arrhythmia; safranin also has a certain degree of anticancer effect; safranin's antimicrobial ability is quite strong; it can also be used for pulmonary arrhythmia or ventricular arrhythmia accompanied by heart failure patients.

Uses and functions of Berberine.

Huanglianxin is an antibacterial drug, is the "national essential drugs catalogue", selected species, the product on the haemolytic streptococcus, staphylococcus aureus, gonococcus and Fuchs', Shigella dysentery bacillus, etc. have antibacterial effect, and have enhanced the phagocytosis of white blood cells, on tuberculosis bacillus, plague bacteria also have different degrees of inhibition.

It is widely used in the treatment of gastroenteritis, bacillary dysentery, etc. It is also effective in tuberculosis, scarlet fever, acute tonsillitis and respiratory tract infections. Traditional Chinese medicine uses Berberis, Phellodendron Bark, three needles and ten gonglao etc. for clearing heat and detoxifying drugs, of which the main active ingredient is Berberine.

Pharmacological Effect of Berberine.

Huanglian is a famous traditional Chinese medicine, which is listed in the Divine Husbandman's Classic of the Materia Medica as the top grade, cold in nature, bitter in flavour, with the effects of clearing heat and drying dampness, diarrhoea and detoxification.

Among them, Berberine has the largest content and is one of the most effective components, which has good therapeutic and health care effects on the cardiovascular system, the nervous system and the digestive system, and is a commonly used Chinese herb. In recent years, some new uses have been found, such as the treatment of primary hypertension, cardiac arrhythmia, hyperlipidaemia, peptic ulcer, type II diabetes mellitus, etc., which can be said to be a new use of an old medicine.

In addition, modern pharmacological studies have confirmed that safranin has significant anti-heart failure, anti-arrhythmia, lower cholesterol, anti-vascular smooth muscle proliferation, improve insulin resistance, anti-platelet, anti-inflammatory and other effects, and thus in the cardiovascular system and neurological disorders will likely have a wide range of important application prospects, and is increasingly being paid attention to!

Product method of  Bulk Berberine Powder.

Isosafrole was isomerised under reduced pressure to isosafrole, which was oxidised to produce piperonal. Piperonyl aldehyde and nitromethane condensation to β-nitro-3,4-dioxomethylidene styrene, further reduction of piperonyl ethylamine [1484-85-1]: piperonyl ethylamine and o-veratraldehyde condensation, and then catalytic hydrogenation, salting, cycling, alkalisation to berberine. Continue to salt with hydrochloric acid to get berberine.

1. Condensation, catalytic hydrogenation, salt will be anhydrous ethanol and o-veratraldehyde mixed, under the stirring and then add piperylene, slightly heated to make all dissolved. Stir for more than 10min to make the condensation reaction complete. The nickel catalyst was mixed with anhydrous ethanol and put into the autoclave together with the condensate.

First through the nitrogen replacement air, and then into the hydrogen, control pressure close to 4MPa, temperature 80-90 ℃, the hydrogenation reaction will be carried out until no longer absorb hydrogen, and continue to keep warm, keep the pressure through the hydrogen 1h until. Cold to 30 ℃, reduce the pressure to 2MPa, static, so that the nickel catalyst settlement, and then use the remaining pressure of the autoclave to press the reaction out.

Pressure filtration to remove the catalyst (immersed in ethanol for the next batch of sets), the filtrate was acidified with hydrochloric acid ethanol at 50 ℃ with stirring to pH 3-4, cooled to 5 ℃, and kept for 4h to make crystallisation. Filtered, washed with a small amount of ethanol, dried to obtain N-2,3-dimethoxybenzyl pepper ethylamine hydrochloride. Yield 84%.

2. cyclization, alkalization, salt in turn glacial acetic acid, acetic anhydride, copper sulfate and sodium chloride into the reaction pot, stirring to 65-70 ℃, slowly add glyoxal, heating to reflux for 20min, cooled to 90 ℃, add N-2,3-dimethoxybenzylpiperonyl ethylamine hydrochloride, heating to 112-114 ℃ reaction 4h. Recycling of acetic acid under reduced pressure to the amount of 70-80% of the feeding, add water. Stir well and filter.

The filter cake was washed with hot water, filtered dry, that is, berberis trihydrochloride crude product. The crude product was first alkalised with lime milk to pH 8-8.5, filtered the obtained berberine hydroxide filtrate and wash solution, adjusted pH 1-2 with dilute hydrochloric acid, filtered, the filter cake was dissolved in hot water, decolourised by adding activated charcoal, filtered, adjusted pH 1-2 with dilute hydrochloric acid, cooled, filtered, washed with water, and dried, i.e., berberine was obtained.

Berberine exists in Berberidaceae and other four families of ten genera of many plants, with the extraction method to produce berberine process is: take three needles or ten underground root wash still, cut into thin slices, sun dry, crushed, plus 0.5% sulfuric acid solution heated immersion 3-4 times, each time for 24 h.

The third and fourth leachate set of immersed in the next batch of raw medicine. The 1st and 2nd leachate filtration, filtrate saturated with sodium chloride, placed, the crystals are separated from the crude product. The crude product is refined by acid-base method to get the finished product. Every hundred kilograms of raw drug can get 0.5kg of finished products.