Plant Extract Biochanin A Raw Materials Powder

CAS:491-80-5

MF:C16H12O5

MW:284.26

EINECS:207-744-7

Specification: 99% min Biochanin A Powder

Sample:Biochanin A Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Biochanin A Powder Usage and Synthesis.

The molecular structure of BCA is similar to that of animal estrogens, and it can competitively bind with estrogen receptors to exert estrogen-like effects. BCA is an important phytoestrogen, which has various beneficial effects on human and animal health, and it can be used in the prevention and treatment of osteoporosis, menopausal syndromes and other diseases. Besides, it also has various pharmacological effects such as anti-tumour, anti-inflammatory, antibacterial, hypoglycemic, antioxidant and neuroprotective.

Uses and functions of Biochanin A.

It has an oestrogen-like effect, inhibits the rise of cholesterol, and also has anti-fungal and anti-tumour effects. Hormone levels in the body has a two-way regulatory effect. There are also anticancer antispasmodic hypolipidemic effect.

Preparation of Biochanin A.

CN201610575057.3 provides a method for synthesising chickpea sprue A, which mainly solves the problems of complicated synthesis process and low yield in the prior art.

It includes the following steps:

Step 1 Preparation of intermediates

Under the condition of room temperature, add phosphorus oxychloride to m-triphenol, p-methoxybenzeneacetonitrile and isopropyl ether, and when the reaction is complete, add an appropriate amount of water k hydrolysis, and use activated carbon to decolourise, i.e., to obtain the intermediate;

Step 2 preparation of crude product

The intermediate obtained in step 1 and methanesulfonyl chloride were shut down in N,N-dimethylformamide (DMF) to generate chickpea budgerigar A crude product;

Step 3 Refining

The chickpea sprouts A crude product obtained in step 2 was recrystallised using ethanol and decolourised by activated carbon, i.e. chickpea sprouts A was obtained.

In vitro studies of  Bulk Biochanin A Powder.

Biochanin A was reported to inhibit protein tyrosine kinase (PTK) of the epidermal growth factor receptor with an IC50 value of 91.5 μM. BiochaninA inhibited the hydrolysis of 0.5 μM cannabinoids by fatty acid amides (FAAH) in vivo in mice, rats, and humans, with IC50 values of 1.8, 1.4, and 2.4 μM, respectively. BiochaninA inhibited the growth of serum- and EGF-stimulated LNCaP and DU-145 cells (IC50 values ranged from 8.0 to 27 μg/ml for serum and 4.3 to 15 μg/ml for EGF), but had no significant effect on the autophosphorylation of the EGF receptor tyrosine