Bulk Gingerol Raw Powder

CAS:23513-14-6

MF:C17H26O4

MW:294.39

EINECS:607-241-6

Specification: 99% min Gingerol Powder

Sample:Gingerol Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White to Light yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Gingerol Powder Physical and Chemical properties.

Gingerol exists in the rhizome of ginger (ginger), yellow oily liquid, taste spicy and bitter. Relative density 1.0713, refractive index 1.5212, boiling point 235~240℃(2.39kPa). Slightly soluble in water, soluble in ethanol, ether, chloroform, benzene, acetic acid. Mainly used as food additives. The content of total gingerols (collectively known as gingerols) in dried ginger is 9.6%. Gingerol market price 360 yuan / kg (purity > 40%).130 yuan / kg (purity > 10%).

Uses and functions of Gingerol.

6-Gingerol can stimulate the mucous membrane, promote gastric juice secretion; in the intestinal tract can inhibit abnormal fermentation, promote gas emission; on the cerebral cortex and vasomotor centre has an excitatory effect, can enhance blood circulation. Modern medical research has confirmed that 6-gingerol has antibacterial, antitumour, antioxidant, anti-inflammatory, antiplatelet effects, but also has a strong heart, prevention and treatment of cardiovascular disease, anti-coagulant, anti-ulcer, anti-vomiting, anti-dizziness, inhibition of prostaglandin synthesis, cholagogues, antiseptic insecticidal, insect repellent and skin care and cosmetic and other biological activities.

6-Gingerol is a bioactive compound with antioxidant activity and is an anti-inflammatory and anti-tumour agent. 6-Gingerol down-regulates the release of inflammatory cytokines from macrophages. It inhibits COX-2 expression by blocking p38 MAP kinase and NF-κB activity.

Preparation of Gingerol.

CN201210553119.2 provides a method for extracting and purifying 6-gingerol from ginger with a simple process, easy operation and high separation efficiency and separation purity. It includes the following steps:

(1) extraction and concentration of gingerol: sliced ginger is placed in a small multifunctional extraction and concentration tank, and extracted with ethanol with a mass concentration of 80~95% at a material-liquid mass-volume ratio of 1:6~15 under heating reflux at 60~80° C. The extraction is carried out for a period of 2~3 hours each time, and each batch of ginger is extracted for two~four times, and the extract from each extraction is flowed into said small multifunctional extraction and concentration tank, and then uniformly concentrated to obtain the ginger extract;

(2) ginger phenol extraction: the said ginger extract is placed in a glass reactor and extracted with ethyl acetate, the number of extraction is 2~4 times, and the extract is combined to obtain the extract; the extract is recovered by rotary evaporator under reduced pressure to obtain the crude extract of ginger phenol; the volume ratio of the said ginger extract to the said ethyl acetate is 1:2~4;

(3) silica gel column chromatography: dissolve said gingerol crude extract in ethyl acetate, and then add said gingerol crude extract 2~4 times the weight of silica gel mixing samples, solvent ethyl acetate evaporated dry, dry on the silica gel column; with petroleum ether-ethyl acetate mixed solvent isocratic elution, thin-layer chromatography TCL detection, collection of eluent containing 6-gingerol part, with the rotary evaporator to recover said eluate under reduced pressure to obtain the crude 6-gingerol; said crude 6-gingerol was again put on a silica gel column, and the purer 6-gingerol was obtained by elution, detection, collection and recovery of solvent according to the above method;

(4) Preparation of HPLC purification: the purer 6-gingerol obtained from said step (3) was dissolved with methanol-water mixed solvent to prepare HPLC purification, eluted with methanol-water mixed solvent as mobile phase isocratic elution, the largest chromatographic peak was collected, and placed on a rotary evaporator and evaporated to a constant weight, that is, to obtain the highly pure 6-Gingerol.

Pharmacological Effect of  Bulk Gingerol Powder.

Anti-coagulation, anti-oxidation, anti-tumour, antihypertensive, cardiovascular, lipid-lowering, anti-atherosclerosis, gastric mucosa protection, hepatoprotective, choleretic, anti-inflammatory, anticough, anti-dizziness and vomiting, central nervous system inhibition, etc., insecticidal, anti-pathogenic microorganisms and bacteriological antiseptic effects.