Magnolol Raw Materials Powder 528-43-8

CAS:528-43-8

MF: C18H18O2

MW:266.33

EINECS:610-903-7

Specification: 99% min Magnolol Powder

Sample: Magnolol Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White to Almost white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Magnolol Powder Usage and Synthesis.

The antioxidant effect of the total phenols of Magnolia officinalis, a phenolic mixture extracted from the traditional Chinese medicine Magnolia officinalis, is an important basis for its biological functions such as antiviral, antibacterial, anti-inflammatory and antidiarrhoeal properties.

Uses and functions of Magnolol.

Used for content determination/identification/pharmacological experiments. Pharmacological effects:Pachypodol has obvious and long-lasting central muscle relaxation, central nervous system inhibition, anti-inflammatory, antibacterial, antipathogenic microorganisms, anti-ulcer, antioxidant, anti-tumour, inhibition of morphine withdrawal, can inhibit platelet aggregation, etc. Pachypodol is used in the treatment of acute enteritis. Bacterial or amoebic dysentery. Chronic gastritis and so on.

Among them, in terms of antibacterial effect, Houpu Phenol has significant antibacterial activity against Gram-positive bacteria, acid-resistant bacteria, filamentous fungi, more significant antibacterial effect on Streptococcus pyogenes, the strongest inhibitory effect on staphylococcus. Clinically, it is mainly used as a drug to eliminate chest and abdominal fullness, sedation of the central nervous system, muscle relaxation in athletes, antifungal, anti-ulcer and so on.

Bioactive substances with antifungal, antibacterial and antioxidant properties and anti-inflammatory activity by interfering with NF -κB signalling.

Pharmacological Effect of Magnolol.

Pachypodol is a dimeric phenylpropanoid compound, white to yellow-brown powder, fragrant, pungent and slightly bitter, is the main active ingredient of Pachypodol, is a small molecule natural product extracted from the dried dry bark, root bark and branch bark of Pachypodol or Pachypodol of the family Magnoliaceae, and has the functions of anti-inflammatory, antibacterial, protection of cardio-cerebral and cerebral vascular systems, anxiolytics and depressions, muscle relaxation, antioxidant, improvement of gastro-intestinal dysfunction and anti-tumour effects. The aqueous extract of Huperzia serrata has a significant effect.

The aqueous extract of Huperzia serrata has a significant arrow poison like effect, its alcohol extract can reduce grip strength, and it has a strong inhibitory effect on spasm induced by strychnine, indohexitoxin and other drugs. It can relieve intestinal spasm induced by barium chloride and hairy fruit rutabine, and has an inhibitory effect on histamine-induced contraction of isolated bronchial smooth muscle in guinea pigs.

A water-soluble alkaloid - Houpalmine (also known as magnolia arrow poisonous alkaloid) isolated from Houpal has a relaxing effect on the transverse muscle, can block the transmission of impulses in the motor end plate, so it is a nerve - muscle blocking effect. And the thick Park phenol on staphylococcus, pneumococcus, haemolytic streptococcus and other gram-positive bacteria and dysentery bacillus, typhoid fever bacillus, Escherichia coli, bacillus subtilis gram-negative bacilli have antibacterial effect.

The ether extract of Huperzia can reduce the spontaneous activity of mice and counteract the excitation caused by methamphetamine or apomorphine, Huperzol and isohuperzol also have significant central inhibitory effects.

Huperzol can cause complete inhibition of spinal reflexes in mice, and ether extract 0.25-1g/kg can present a central inhibitory effect that makes any reflex disappear.

Raw and roasted ginger products of Magnolia officinalis have anti-gastric ulcer effects on rat pylorus ligation-type and stress-type II acute experimental gastric ulcer models, especially ginger products have stronger effects.

With the thick Park phenol 100mg/kg intraperitoneal injection or subcutaneous injection, the water immersion bound stress ulcer disease, mercaptoethylamine ulcer, pylorus ligation ulcer have inhibitory effect, but also can antagonise the role of central gastric acid secretion stimulant.

Characteristic of  Bulk Magnolol Powder.

Brown to white fine powder, the monomer is colourless needle-like crystals, melting point is 102 ℃, easily soluble in benzene, chloroform, acetone and other commonly used organic solvents, insoluble in water, easily soluble in caustic alkali dilute solutions