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  • Pharmaceutical intermediates API sulfadimethoxine Powder

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    Product Overview:

    Sulfadimethoxine is a synthetic antibacterial drug widely used in clinical practice. The antibacterial mechanism of sulfonamides is mainly bacteriostatic, inhibiting the growth and reproduction of bacteria. It is effective against most Gram-positive bacteria, some Gram-negative bacteria, and ineffective against rickettsiae, mycoplasmas, viruses, etc.

    Pharmaceutical intermediates API sulfadimethoxine Powder Attributes

    Pharmaceutical intermediates API sulfadimethoxine Powder

    CAS:122-11-2

    MF:C12H14N4O4S

    sulfadimethoxine Raw

    MW:310.33

    EINECS:204-523-7

    Specification: 99% min sulfadimethoxine Powder

    Sample:sulfadimethoxine Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceutical intermediates API sulfadimethoxine Powder Details

    sulfadimethoxine Powder Usage and Synthesis.

    Sulfonamides can be divided into sulfonamides for systemic infections, enteric sulfonamides, and topical sulfonamides according to the nature of their action and the length of their half-life.

    Sulfonamides for systemic infections can be divided into short-acting sulfonamides (half-life of about 6 hours), including sulfadiazine, sulfamethazine, sulfamethoxazole, sulfisoxazole, etc.; intermediate-acting sulfonamides (half-life of about 12 hours), including sulfadiazine, sulfamethoxazole, sulfamethoxazole, etc.; long-acting sulfonamides (half-life of more than 24 hours), including sulfamethoxazole, sulfamethoxazole, sulfamethazine, sulfadiazine; sulfamethoxazole, sulfamethoxine, sulfadoxine, sulfamethoxazine; sulfadoxine-p-methoxazine; sulfamethoxydiazide; sulfadoxopridazine; sulfamethoxine; sulfamethoxine-octopyridazine; sulfamethoxazine , sulfadimethoxine; sulfamethoxypyridazine, sulfadimethoxine-o-dimethoxypyrimidine, and others.

    Sulfonamide for intestinal use mainly plays a bacteriostatic role in the intestinal tract, there are sulfadimethoxine, sulfosulfathiazole, phthalosulfathiazole, phthalosulfonylacetamide (restramil), sulfasalazine, and so on. Topical sulfonamides mainly include sulfacetamide sodium, methosulfamethoxazole, silver sulfadiazine and so on.

    sulfadimethoxine Powder

    Uses and functions of sulfadimethoxine.

    Antibacterial effect and clinical efficacy are similar to SD. Internal absorption is rapid and excretion is slow, the effect is maintained for a long time, the rate of acetylation in vivo is low, and it is not easy to cause damage to the urinary tract.

    In addition to broad-spectrum antibacterial effect, this product also has significant anti-coccidial, anti-Toxoplasma gondii effect. Mainly used for the prevention and treatment of calves, chickens, rabbits, coccidiosis, but also for the prevention and treatment of chicken infectious rhinitis, avian cholera, Kashiwagi leukocytosis, toxoplasmosis in dogs and pigs (often used in conjunction with ethyl pyrimethamine), and dogs, cats, nocardiosis, but also for the prevention and treatment of bacterial gill disease, erectile scales, vibrio disease, eel disease, carp fish boils, and so on.

    Sulfonamide antibiotics that block the synthesis of dihydrofolate by inhibiting dihydrofolate synthase.

    Mode of action: Inhibits folate synthesis in prokaryotes. Antimicrobial spectrum: Gram-positive bacteria, Gram-negative bacteria, Chlamydia Antibiotic mechanism: alteration of dihydrofolate synthase or alternative pathways of folate synthesis.

    sulfadimethoxine Raw

    Physiological Effect of sulfadimethoxine.

    Sulfadimethoxine is an anti-microbial sulphur drug that blocks the synthesis of dihydrofolate by inhibiting dihydropyridine synthase.

    Sulfadimethoxine is a competitive inhibitor of p-aminobenzoic acid (PABA), which is required for the synthesis of folic acid by bacteria. It induces CYP3A4 expression and acetylation by N-acetyltransferase. It exhibits gender-dependent pharmacokinetics and is metabolised by the male-specific CYP2C11 isoform. Sulfadimethoxine is bacteriostatic.

    An anti-microbial sulphur drug. Induces CYP3A4 expression and acetylation by N-acetyltransferase. Exhibits gender-dependent pharmacokinetics and is metabolised by the male-specific CYP2C11 isoform.

    API sulfadimethoxine Raw Powder

    Drug interactions of  Bulk sulfadimethoxine Powder.

    1、Combining with urine alkalinising drugs can enhance the solubility of the product in alkaline urine and increase excretion.

    2, can not be used in combination with p-aminobenzoic acid (PABA), PABA can be replaced by the bacterial uptake of this product, the two antagonistic to each other.

    3, the following drugs and this product with the use of this product, this product can replace the protein binding sites of these drugs, or inhibit their metabolism, so that the drug action time is prolonged or toxicity, therefore, when these drugs and sulfonamides at the same time, or in the application of this product after the use of the dose needs to be adjusted. Such drugs include oral anticoagulants, oral hypoglycaemic agents, methotrexate, phenytoin sodium and sodium thiopental.

    The adverse effects of these drugs on the haematopoietic system may be enhanced when combined with myelosuppressive drugs. If there are indications for the co-administration of these two drugs, close observation should be made for possible toxic reactions.

    5, and contraceptive drugs (estrogen class) for a long time may lead to reduce the reliability of contraception, and increase the chance of bleeding outside the menstrual period.

    6, and thrombolytic drugs, may increase its potential toxic effects.

    7, and hepatotoxic drugs, may cause an increase in the incidence of hepatotoxicity. Liver function should be monitored in such patients, especially those who have been using the drug for a long time and have a history of liver disease in the past.

    8, with light-sensitive drugs, may occur light-sensitive additive effect.

    The need for vitamin K is increased in patients treated with this product.

    10, should not be used in combination with urotropin, because urotropin can be decomposed in acidic urine to produce formaldehyde, the latter can be formed with the product insoluble precipitates, so that the risk of crystalluria increased.

    11, this product can replace the plasma protein binding site of POTASONE, when the two are used together can enhance the role of POTASONE.

    12, sulfinpyrazone and this product can reduce the latter from the renal tubular secretion, resulting in increased blood concentrations and persistent, resulting in toxicity, so in the application of sulfinpyrazone during or after the application of its treatment may need to adjust the dose of this product. When sulfinpyrazone therapy is prolonged, it is advisable to monitor the blood concentration of sulfonamides to help dose adjustment and ensure safe administration.

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