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  • Raw material intermediate Bulk Sulfaguanidine solution Powder

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    Product Overview:

    Sulfanilamide and sulfaguanidine used to be the commonly used varieties of sulfonamides, due to the high toxicity, generally not used as the drug of choice, now they and acetamidobenzenesulfonyl chloride are only used as intermediates in the production of sulfonamides. Sulfaguanidine, also known as sulfaguanidine, dysentery tablets, the earliest sulfonamides used for intestinal infections, sulfaguanidine molecular structure has a strong basic guanidine group, the dissociation degree is large, the fat solubility is small, although there is a certain amount of intestinal absorption after intake, but not enough to reach the effective blood concentration, so it is not used for systemic infections.

    Raw material intermediate Bulk Sulfaguanidine solution Powder Attributes

    Raw material intermediate Bulk Sulfaguanidine solution Powder

    CAS:57-67-0

    MF: C7H10N4O2S

    Bulk Sulfaguanidine solution

    MW:214.24

    EINECS:200-345-9

    Specification: 99% min Sulfaguanidine solution Powder

    Sample: Sulfaguanidine solution Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Store at -20°C

    Shelf Life: 2 Years

    Test Method: HPLC

    Raw material intermediate Bulk Sulfaguanidine solution Powder Details

    Sulfaguanidine solution Powder Usage and Synthesis.

    Sulfanilamide and sulfaguanidine used to be the commonly used varieties of sulfonamides, due to the high toxicity, generally not used as the drug of choice, now they and acetamidobenzenesulfonyl chloride are only used as intermediates in the production of sulfonamides. Sulfaguanidine, also known as sulfaguanidine, dysentery tablets, the earliest sulfonamides used for intestinal infections, sulfaguanidine molecular structure has a strong basic guanidine group, the dissociation degree is large, the fat solubility is small, although there is a certain amount of intestinal absorption after intake, but not enough to reach the effective blood concentration, so it is not used for systemic infections. But can maintain a higher concentration in the intestine, mostly used for bacterial infections of the digestive tract. Such as gastroenteritis, dysentery, etc. Combined with antimicrobial potentiator methotrexate (TMP) or dimethoate (DVD), its antimicrobial effect is significantly enhanced.

    Sulfaguanidine solution Powder

    Uses of Sulfaguanidine solution.

    It is the drug of choice for the treatment of leprosy, applicable to the treatment of all types of leprosy, and can improve clinical symptoms. For general mucosal lesions improve faster, skin lesions improve more slowly, neuropathy is even slower, so the course of treatment is long, easy to produce drug resistance, not easy to cure, in addition, can also be used to treat herpes-like dermatitis, lupus erythematosus, psoriasis, podoconiosis and malaria. Preparation for tablets.

    This product is a sulfonamide drug, used for intestinal antibacterial infections, such as bacterial dysentery enteritis, but also for intestinal surgery before the prevention of infection. In the pharmaceutical industry, it is generally used as an important raw material for sulfadiazine drugs such as SM2 and SD.

    Sulfadiazine drugs, used in bacterial dysentery, enteritis and so on.

    Sulfadiazine is a low-grade sulfonamide that can inhibit bacteria. It is mainly used for the production of sulfadiazine, sulfadimidine and other high-level sulfonamides.

    Bulk Sulfaguanidine solution

    Preparation methods of Sulfaguanidine solution.

    Preparation methods:

    1, The finished product of sulphonamidine can be made by melting sulphonamide and guanidine nitrate in soda ash and condensing under reduced pressure.

    2, It can be produced by reacting acetylsulfamoyl chloride with guanidine nitrate in the presence of sodium hydroxide in a mixed solution of acetone and water.

    3, Sulfamidine can be produced by catalytic hydrogenation of p-nitrobenzenesulfonyl chloride as raw material to produce p-aminobenzenesulfonyl chloride, then ammoniated to produce sulfanilamide, and then reacted with guanidine nitrate.

    Drug interactions:

    1, the simultaneous application of urine alkalinising drugs can enhance the solubility of the product in alkaline urine and increase excretion.

    2, Sulfaguanidine can not be combined with p-aminobenzoic acid, p-aminobenzoic acid can replace the product by bacterial uptake, and the two are mutually antagonistic. Also should not be combined with local anaesthetics containing p-aminobenzoyl, such as procaine, bupivacaine and so on.

    3, For those taking estrogen-based contraceptives, the simultaneous application of sulfaguanidine for a prolonged period of time may lead to a decrease in the reliability of contraception and increase the chance of extra-menstrual bleeding.

    4, An additive effect of photosensitivity may occur when combined with photosensitive drugs.

    5, The need for vitamin K is increased in those treated with this product.

    Sulfaguanidine solution Powder

    Product Method of Bulk Sulfaguanidine solution Powder.

    Sulfanilamide condensed with Guanidine Nitrate

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