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  • Antibacterial apis Metronidazole CAS 489-32-7

    • Antibacterial apis Metronidazole CAS 489-32-7
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    Product Overview:

    Metronidazole is a nitroimidazole antibiotic, also known as methotrexate, metronidazole, metronidazole, methotrexate, methotrexate, kills anaerobic microorganisms, and the metabolites it generates when it is reduced in the human body also have an anaerobic effect, inhibiting bacterial DNA synthesis, thus interfering with bacterial growth, reproduction, and ultimately bacterial death, anti-anaerobic bacterial Pu including: anaerobic bacterial bacteria fragile mimic bacillus, clostridium difficile (due to the Clostridium fragilis, Clostridium perfringens (so named because of the shape of the bacterium's body, which is pointed at both ends), Tetanus bacillus, Digestive Cocci, Digestive Streptococci, and Giardia Flagellates. It was initially used for the treatment of vaginal trichomoniasis with very significant clinical results.

    Antibacterial apis Metronidazole CAS 489-32-7 Attributes

    Antibacterial apis Metronidazole CAS 489-32-7

    CAS:443-48-1

    MF: C6H9N3O3
    98% Metronidazole

    MW:171.15

    EINECS:207-136-1

    Specification: 99% min Metronidazole

    Sample:Metronidazole Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: white to light yellow

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Antibacterial apis Metronidazole CAS 489-32-7 Details

    Metronidazole Usage and Synthesis.

    The efficacy of metronidazole on amoebiasis in the body tissues and intestinal lumen is remarkable, and it is also the first choice of drug for the treatment of worms in human body. The mechanism of action is to inhibit the redox reaction of amoebic protozoa, so that the protozoa nitrogen chain breaks down and acts.

    In vitro tests have proved that when the drug concentration is 1~2mg/L, lysogenic amoeba can undergo morphological changes in 6~20 hours, and all of them can be killed within 24 hours, and the concentration of 0.2mg/L can kill lysogenic amoeba within 72 hours, which has been widely used in the treatment of intestinal and extra-intestinal amoebiasis (e.g., amoebic liver abscess, pleural amoebiasis, etc.).

    As nitroimidazole antibiotics and ethanol, nicotine and other interactions, interfere with the oxidation process of ethanol, can cause disulfiram reaction, resulting in a faster heart rate, lower blood pressure and other symptoms, so the patient should avoid contact with alcohol-containing beverages and less smoking during the medication, in order to avoid the occurrence of adverse drug reactions.

    Metronidazole CAS 443-48-1

    Uses and functions of EMetronidazole.

    It has been used for the treatment of vaginal trichomoniasis since 1959 and for intestinal and extra-intestinal amebiasis since 1970, with high efficacy, low toxicity and wide application. It has mutagenic and teratogenic effects on animal experiments.

    Powerful antibacterial effect against most anaerobic bacteria.

    Used in the treatment of amebiasis, trichomoniasis and anaerobic infections.

    98% Metronidazole

    Pharmacological Effect of Metronidazole.

    Nitro of metronidazole, in the anaerobic environment by anaerobic bacteria reduced to an active product with cytotoxicity, inhibited the DNA synthesis of sensitive bacteria, so that the bacterial death and show anti-anaerobic effect, most anaerobic bacteria with strong antibacterial effect, but for aerobic bacteria and parthenogenetic anaerobes is ineffective.

    It is mainly used for the prevention and treatment of infections caused by anaerobic bacteria, such as respiratory tract, digestive tract, abdominal and pelvic pus infections, infections of soft tissues of the skin, bone and bone joints, and endocarditis, septicaemia and meningitis caused by Mycobacterium fragileis, and it is also widely used for the prevention and treatment of anaerobic infections of the oral cavity.

    Metronidazole Powder

    Product Method of Bulk Metronidazole.

    Obtained by addition of 2-methyl-5-nitroimidazole (see 25010) to ethylene oxide. Dissolve 2-methyl-5-nitroimidazole in formic acid, add ethylene oxide one at a time at 30-40°C and add sulphuric acid in between additions. After addition, the reaction was 1 h. Recover formic acid under reduced pressure, add water to dissolve and cool to 10 ℃, filter. The filtrate was adjusted to pH=10 with sodium hydroxide solution, left to cool, filtered, and washed with water to nearly medium alteration. Recrystallised with water. Activated carbon decolourisation, that is, to obtain metronidazole.

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