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API Spectinomycin Hydrochloride Raw Materials Powder
Product Overview:
Spectinomycin hydrochloride is produced by Streptomyces sp. It is an aminoglycoside rapid bactericidal antimicrobial agent made by the combination of a neutral sugar and an aminocyclic alcohol with a glycosidic bond, which also has the name of Spectinomycin. It was discovered by American Mason in 1961 in the last century. It is used in the veterinary treatment of livestock and poultry clinics, mainly for the treatment of sensitive bacterial infections caused by Escherichia coli, Salmonella, Pasteurella and Mycoplasma and other diseases caused by
API Spectinomycin Hydrochloride Raw Materials Powder Attributes
CAS:21736-83-4
MF:C14H25ClN2O7
MW:368.81
EINECS:244-554-3
Specification: 99% min Spectinomycin Hydrochloride Powder
Sample: Spectinomycin Hydrochloride Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: White Powder
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
API Spectinomycin Hydrochloride Raw Materials Powder Details
Spectinomycin Hydrochloride Powder Usage and Synthesis.
The antibacterial mechanism of Spectinomycin Hydrochloride is the same as other aminoglycoside antimicrobials, it also enters into the bacterial cell, and selectively acts on the 30s subunit of the bacterial cell nuclear proteasome, which produces a strong inhibition of bacterial cell protein synthesis, and produces a strong killing effect on sensitive bacteria.
Injectable Spectinomycin Hydrochloride is the first speciality drug for gonorrhoea developed by LUXA Pharmaceuticals in China. Injectable Spectinomycin Hydrochloride has been recommended as the first choice of gonorrhoea by WHO and the Ministry of Health of the People's Republic of China.
LUCA is the only enterprise with the production capacity of macrolide hydrochloride API in China, and has been ranked first in the domestic macrolide powder injection market for eight consecutive years.
Uses of Spectinomycin Hydrochloride.
Mainly used for the treatment of urethritis, cervicitis, proctitis and acute gonorrhoea caused by gonococci
For the treatment of G-bacteria, Mycoplasma and the co-infection of Mycoplasma and bacteria. Mainly used for the prevention and treatment of E. coli, Salmonella, Pasteurella, Mycoplasma infections in piglets.
Spectinomycin Hydrochloride belongs to broad-spectrum and rapid bactericides, it has strong effects on Escherichia coli, Salmonella, Pasteurella, Proteus, Haemolytic Streptococcus, Streptococcus pneumoniae, Pneumococcus, and so on; therefore, it has a better clinical therapeutic effect in the treatment of infectious diseases caused by the above sensitive bacteria.
It has inhibitory effect on Gram-positive and negative bacteria. It has strong antibacterial effect on gonococcus, and also has good antibacterial activity on gonococcus that produces B-lactamase, which is a new type of special effect drug for gonorrhoea.
Characteristic of Spectinomycin Hydrochloride.
Spectinomycin belongs to alkaline antimicrobial, the stronger the alkaline the stronger its antimicrobial potency; but Spectinomycin does not dissolve in water, so the most commonly used commercialised prodrug in China is Spectinomycin Hydrochloride. It is white or off-white crystalline powder under the standard of quality assurance; it is easily soluble in water, and the aqueous solution dissolved in water shows acidic test results, and the pH of its 1% aqueo.
Pharmacological Effects of Spectinomycin Hydrochloride.
Spectinomycin Hydrochloride is an aminoglycoside antibiotic produced by Streptomyces streptomycesspectabilis, which has high antibacterial activity mainly against Neisseria gonorrhoeae, and good antibacterial activity against β-lactamase-producing Neisseria gonorrhoeae; and moderate antibacterial activity against many Enterobacteriaceae.
Prophidium and Pseudomonas aeruginosa are usually resistant to this product; strains resistant to this product are often still sensitive to streptomycin, gentamicin, tobramycin and so on. This product has good effect on Mycoplasma lysodeikticum, and has no activity on Chlamydia trachomatis and Syphilis spirochetes.
The mechanism of action of Spectinomycin Hydrochloride is to bind to the 30S subunit of bacterial ribosome and inhibit bacterial protein synthesis