Veterinary medicine Amoxicillin CAS 26787-78-0

CAS:26787-78-0

MF: C16H19N3O5S

MW:365.4

EINECS:248-003-8

Specification: 99% min Amoxicillin

Sample:Amoxicillin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: light yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Amoxicillin Usage and Synthesis.

Amoxicillin, also known as amoxicillin or amoxicillin, is one of the most commonly used penicillin-based broad-spectrum β-lactam antibiotics, a white powder with a half-life of about 61.3 minutes. It is stable under acidic conditions, with a gastrointestinal absorption rate of 90%, with strong bactericidal effect and strong ability to penetrate cell membranes, and is also one of the more widely used semi-synthetic penicillins in clinical application, with preparations such as capsules, granules, tablets, and injections, and is now often combined with clavulanic acid and sulbactam to make injections.

The drug is mainly used to treat inflammation due to upper and lower respiratory tract infections, such as otitis media, sinusitis, acute urethritis, and other more serious inflammation.

Moreover, Amoxicillin has a wide range of effects, works quickly, and can be well absorbed by the stomach and intestines after swallowing, making it a better antibiotic drug.

Uses and functions of Amoxicillin.

Amoxicillin is one of the more common anti-inflammatory medications and is so effective that it has been one of the must-have medications that many patients keep in their homes. This product is well absorbed orally. Taking the same amount of drugs, the serum drug concentration of this product is about twice as high as that of ampicillin. It is commonly used for respiratory, urinary tract and biliary tract infections caused by sensitive bacteria, as well as typhoid fever. Amoxicillin's role is mainly in the anti-infective treatment of various systems, as follows:

1. Upper respiratory tract infections: otitis media, sinusitis, pharyngitis, tonsillitis and so on. Lower respiratory tract infections: acute bronchitis, pneumonia, etc.

2. Various skin and soft tissue infections.

3. Genitourinary tract infections: acute bacterial nephritis, acute cystitis, acute urethritis, acute simple gonorrhoea.

4. Amoxicillin can also be used in triple combination with metronidazole and omeprazole to eradicate gastric and duodenal Helicobacter pylori and reduce the recurrence rate of peptic ulcer.

Amoxicillin can be used as a broad-spectrum semi-synthetic penicillin. It is clinically used for the treatment of tonsillitis, laryngitis, pneumonia, chronic bronchitis, urinary system infections, skin and soft tissue infections, purulent pleurisy, hepatobiliary system infections, sepsis, typhoid fever, dysentery and so on.

Amoxicillin is an antimicrobial spectrum drug, and its action and application are similar to that of chlorambucil penicillin, with the advantage of a low serum protein binding rate and a blood concentration that is more than two times higher than that of ampicillin. Hydroxybenzylpenicillin is a better efficacy, safety and effective and drugs.

It was developed by Beecham in 1968.

Drug interactions of Amoxicillin.

1. Probenecid competitively reduces renal tubular secretion of the drug, and concomitant use of both drugs may result in increased amoxicillin blood concentrations and prolonged half-life. 

2. The risk of haemorrhage is increased with warfarin.

Product Method of Bulk Amoxicillin.

It is obtained by condensation of 6-APA with N-(3-ethoxycarbonyl-1-methylethenyl) p-hydroxyphenylglycine sodium salt.6-APA is an important raw material for the production of various semisynthetic penicillins. At present, it is produced industrially by cleavage of natural penicillin (penicillin G or penicillin V) by the enzyme penicillin amidase produced by microorganisms.