Antibiotic drugs Oxytetracycline Hydrochloride Powder

CAS:2058-46-0

MF:C22H25ClN2O9

MW:496.89

EINECS:218-161-2

Specification: 99% min Oxytetracycline Hydrochloride Powder

Sample:Oxytetracycline Hydrochloride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Yellow Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Oxytetracycline Hydrochloride Powder Usage and Synthesis.

Oxytetracycline hydrochloride, the name of a western medicine. Common dosage forms include tablets. It is a tetracycline antibiotic. It can be used for the treatment of rickettsial diseases, Mycoplasma spp. infections,Chlamydia spp. infections, regression fever, brucellosis, cholera, rabbit fever, bubonic plague, and soft chancre. It should be used in combination with aminoglycosides in the treatment of brucellosis and plague.

Uses and functions of Oxytetracycline Hydrochloride.

1, Oxytetracycline Hydrochloride can be used as the drug of choice for the following diseases:

(1) Rickettsial diseases, including epidemic typhus, endemic typhus, Rocky Mountain fever, Scrub typhus and Q fever.

(2) Infections of the genus Mycoplasma.

(3) Infections of the genus Chlamydia, including psittacosis, venereal disease, lymphogranuloma, nonspecificurethritis, salpingitis, cervicitis, and trachoma.

(4) Regression fever. (5) Brucellosis. (6) Cholera. (7) Rabbit fever. (8) Bubonic plague. (9) Noma.

It should be used in combination with aminoglycosides for the treatment of brucellosis and plague.

2, due to the current common pathogenic bacteria on Oxytetracycline Hydrochloride drug resistance phenomenon is serious, only in the pathogenic bacteria on the product is sensitive, can be used as a choice of drugs; on

Oxytetracycline Hydrochloride sensitive Escherichia coli, Enterobacter aerogenes, Lofexobacterium, Shigella spp,Haemophilus influenzae ( (respiratory tract infections only) and Klebsiella spp. (respiratory and urinary tractinfections only) and other gram-negative bacilli infections. This product should not be used for any type of staphylococcal or haemolytic streptococcal infection.

3、Oxytetracycline Hydrochloride can be used in patients with allergy to penicillins for tetanus, gas gangrene, yaws,syphilis, gonorrhoea and leptospirosis, as well as Actinomyces spp. and Listeria monocytogenes infections.

4、Oxytetracycline Hydrochloride can be used as adjuvant therapy for patients with acute intestinal amebiasis and moderate or severe acne.

Physiological Effect of Oxytetracycline Hydrochloride.

1, Oxytetracycline Hydrochloride is a broad-spectrum bacteriostatic agent, many Rickettsia spp., Mycoplasma spp.,Chlamydia spp., spirochetes, amoebae and some Plasmodium spp. are also sensitive to this product. Enterococcus spp. are resistant to it.Others such as Actinobacillus spp, Bacillus anthracis, Listeria monocytogenes, Clostridium difficile, Nucella spp,

Vibrio spp, Brucella spp, Campylobacter spp, and Yersinia spp are susceptible to the product.Oxytetracycline Hydrochloride has some antibacterial activity against gonococci and meningococci, but penicillin-resistant gonococci are also resistant to hygromycin.

Over the years, due to the widespread use of tetracyclines, there has been a serious phenomenon of resistance to hygromycin in common clinical pathogens, including gram-positive bacteria such as staphylococci and most gram-negative bacilli. Cross-resistance exists between different varieties of tetracycline antibiotics.

2, Oxytetracycline Hydrochloride mechanism of action is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibit the growth of peptide chains and affect the synthesis of bacterial proteins.

Drug interactions of  Bulk Oxytetracycline Hydrochloride Powder.

1、When used with acid-making drugs such as sodium bicarbonate, due to the increase of intragastric pH, it can make the absorption of this product reduced and the activity is reduced, so acid-making drugs should not be taken within 1-3 hours after taking this product.

2、Drugs containing calcium, magnesium, iron and other metal ions can form insoluble complexes with this product, so that the absorption of this product is reduced.

3, with the general anaesthetic drug methoxyflurane when used together, can enhance its nephrotoxicity.

4, and strong diuretic drugs such as furosemide and other drugs when used together can aggravate renal function damage.

5, and other hepatotoxic drugs (such as anti-tumour chemotherapy drugs) when used together can aggravate liver damage.

6, lipid-lowering drugs Kaolai enamine or Kaolai Tipo can affect the absorption of this product, must be separated from the hours to take.

7, Oxytetracycline Hydrochloride can reduce the effect of contraceptive pills, increase the possibility of bleeding outside the menstrual period.

8, Oxytetracycline Hydrochloride can inhibit the activity of plasma plasminogen, so patients receiving anticoagulant therapy need to adjust the dose of anticoagulants.