Feed Additive Salinomycin Sodium Premix CAS 55721-31-8

CAS:55721-31-8

MF: C42H71NaO12

MW:791

EINECS:611-309-0

Specification: 99% min Salinomycin Sodium Premix

Sample:Salinomycin Sodium Premix Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White or Yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Salinomycin Usage and Synthesis.

Salinomycin is a monocarboxylic acid polyether class of animal antibiotics, most of the gram-positive bacteria and a variety of coccidia have a strong inhibitory and killing effect, it is not easy to produce drug resistance and cross-resistance, rapid excretion, very low residue, used for pigs to prevent and control diarrhoea, to promote the growth of, and to improve the survival rate of, mainly used in poultry to prevent coccidia researchers have found that a kind of compound can be "aimed at" and kill the cancer stem cells in the laboratory study period, its effectiveness in killing breast cancer stem cells in mice is 100 times higher than the ordinary anti-cancer drug Teksol (Taxol). During the laboratory study, its effectiveness in killing breast cancer stem cells in mice was 100 times higher than that of the common anticancer drug Taxol.

Uses and functions of Salinomycin.

Salinomycin sodium is a safe and effective anticoccidial drug, it also has an inhibitory effect on most gram-positive bacteria, and is effective against coccidia, tender Ehrlichia, toxigenic Ehrlichia, giant Ehrlichia, stacked Ehrlichia and harlequin coccidia in chickens. It can be used in chicken feed, the dosage is 50-60g/t, prohibited during egg-laying period, the withdrawal period is 5 days. It is contraindicated for equine animals and will be fatal after use; prohibited from being used simultaneously with Taimycin and Duchenomycin.

Physiological Effect of Salinomycin.

Controls and reduces the number of enteric pathogenic bacteria.

Reduce the production of microbial toxins, e.g. biogenic amines and ammonia.

Prevent overgrowth of microorganisms in the small intestine that compete with the animal for nutrients.

Regulates the ecological balance of intestinal flora and improves survival rate.

Controls the morbidity and mortality of chicken coccidiosis.

In vivo studies of Bulk Salinomycin.

Salinomycin (5 and 10 mg/kg) significantly supresses the average tumor volume and tumor weight. Salinomycin hinders the U251 human glioma cell growth in vivo via inhibition of angiogenesis with involvement of AKT and FAK dephosphorylation. Salinomycin (0.5 mg/kg b.wt.) enhances the mean survival time of the tumor bearing Swiss albino mice.