Veterinary Medicine Mebendazole Powder CAS 31431-39-7 Raw Materials

CAS: 31431-39-7

MF: C16H13N3O3

MW: 295.29

EINECS: 250-635-4

Specification​: 99% min Mebendazole

Sample: Mebendazole Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Mebendazole Powder Usage and Synthesis.

Veterinary Medicine Mebendazole is a broad-spectrum anthelmintic that completely kills hookworm and whipworm eggs and partially kills roundworm eggs.

Mebendazole Powder is also an oxidative phosphorylation uncoupler, which inhibits fenugreek reductase in mitochondria and reduces glucose transport, thereby affecting ATP production. Effective as an anthelmintic against gastrointestinal nematodes in animals.

Mebendazole Raw Materials can be mixed with feed. 

Mebendazole Raw Materials can be mixed with feed. It is effective against a variety of intestinal worms such as roundworms, dawn, whipworms, hookworms and other intestinal worms, and is the first choice of anti-flagellate drugs.

Uses and functions of Mebendazole Powder.

Mebendazole is a broad-spectrum anthelmintic, which can completely kill the eggs of hookworms and whipworms, and partially kill the eggs of roundworms. It has a strong affinity for β-microtubule proteins of worms, which can be bound to them at a very low concentration, and can inhibit their microtubule polymerization by affecting their glucose metabolism and related energy production.

It can inhibit the polymerization of microtubules by affecting the sugar metabolism and energy production of the worm, causing the disappearance of the epidermis or intestinal cells of the worm, and can selectively and irreversibly inhibit the worm from taking up glucose and other nutrients from the intestinal tract, and finally lead to the death of the worm.

It is suitable for the treatment of human and animal infections caused by whipworms, pinworms, hookworms, tapeworms, cestodes, fecal roundworms, roundworms and other single or multiple helminths, but is not effective against encapsulated diseases.

Pharmacological Effects of Mebendazole Powder.

Mebendazole suspension can inhibit the uptake of glucose by intestinal parasites, leading to depletion of stored glycogen in the body of the worms and reducing the formation of adenosine triphosphate in the body of the worms, but it does not affect the glucose level in the blood of the host. Ultrastructural observations.

Mebendazole suspension could cause microtubule degeneration in the pericytes and cytoplasm of enterocytes of the worms, which led to the accumulation of endocrine particles in the Golgi apparatus, producing transport blockage, cytoplasmic lysis, and complete denaturation of the absorbing cells, thus causing the death of the worms.

Combination with drugs that inhibit hepatic microsomal enzyme activity, such as cimetidine, inhibits the metabolism of mebendazole and increases the blood concentration.

Combining with drugs that induce hepatic microsomal enzymes such as phenytoin or carbamazepine can accelerate the metabolism of Mebendazole suspension and reduce the blood concentration.

Production method of Mebendazole Powder.

4-Chloro-3-nitrobenzoic acid is chlorinated with sulfoxide chloride, condensed with benzene under the catalysis of aluminum trichloride, then aminated and reduced to obtain 3,4-diaminobenzophenone, and then made into Mebendazole by cyclization. 3,4-diaminobenzophenone hydrochloride can also be added to the mixture obtained by the reaction of S-methyl isothiourea sulfate, methyl chloroformate and sodium hydroxide, and then add sodium acetate, and then react for 45min at 85℃, which can also produce mebendazole.