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  • Pharmaceutical Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply

    • Pharmaceutical  Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply
    • Pharmaceutical  Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply
    • Pharmaceutical  Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply storehouse
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    • Pharmaceutical  Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply quality testing
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    Product Overview:

    Trimethoprimlactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor.Trimethoprimlactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria (Gram-positive and Gram-negativeaerobicbacteria). Trimethoprimlactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria (Gram-positive and Gram-negativeaerobicbacteria).Trimethoprimlactic is used in the study of urinary tract infections, shigellosis and Pneumocystis carinii pneumonia.

    Pharmaceutical Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply Attributes

    Pharmaceutical  Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply

    CAS:23256-42-0

    MF: C17H24N4O6

    MW: 380.4

    EINECS: 245-533-1

    Specification​: 99% min  Trimethoprim lactate salt Powder

    Sample:  Trimethoprim lactate salt Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Portal:https://henrikang.en.made-in-china.com/

    Pharmaceutical Trimethoprim lactate salt Raw Materials Powder CAS 23256-42-0 API Factory Supply Details

    Trimethoprim lactate salt Powder Usage and Synthesis.

    Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF). Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability.

    Trimethoprim lactate salt Powder

    Uses and functions of  Trimethoprim lactate salt Powder.

    Trimethoprim lactate salt is the predominant antibacterial agent. It has dihydrofolate reductase inhibitory activity and prokaryotic enzyme selectivity. It has been used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.

    Trimethoprim lactate salt Powder

    Pharmacological Effects of  Trimethoprim lactate salt Powder.

    1, this product and sulfonamides, can make the bacterial folic acid metabolism was doubly blocked, to enhance its role up to several times to dozens of times. It presents bactericidal effect, and also reduces the production of drug-resistant strains.

    2, the mutual effect of drugs; TMP can enhance the antibacterial effect of tetracycline, penicillin, erythromycin, gentamicin, etc., and the combined use of safranin, safranin antibacterial effect is significantly enhanced for broad-spectrum non-selective antimicrobial drugs.

    Trimethoprim lactate salt Powder

    Production method of  Trimethoprim lactate salt Powder.

    Trimethoprim lactate salt binds to sulfamethoxazole and interferes with folate cell metabolism in bacterial cells by blocking nucleotide synthesis. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolate (DHF) and tetrahydrofolate (THF), the basic precursor of the thymine synthesis pathway, and interferes with this pathway to inhibit bacterial DNA synthesis.

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