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  • Pharmaceuticals Raw Materials API Amphotericin B Powder

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    Product Overview:

    Amphotericin B, also known as Lushanomycin, is a polyene antifungal antibiotic isolated from the culture fluid of Streptomyces (Streptomycesnodosus), and Lushanomycin produced by actinomycetes isolated from the soil of Mount Lushan, Jiangxi Province, China, in 1974, it has significant inhibitory effects on Cryptococcus neoformans, Dermatophagoides, Brasilbacterium, Histoplasma capsulatum, Schenker's siderophore, Pseudoalbicans and several Nocardia, etc. MIC is generally 0.2~0.5μg/ml. MIC is 0.2~0.5μg/ml.

    Pharmaceuticals Raw Materials API Amphotericin B Powder Attributes

    Pharmaceuticals Raw Materials API Amphotericin B Powder

    CAS:1397-89-3

    MF:C47H73NO17

    Amphotericin B Raw Materials

    MW:924.08

    EINECS:215-742-2    

    Specification: 99% min Amphotericin B Powder

    Sample:Amphotericin B Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:Yellow Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceuticals Raw Materials API Amphotericin B Powder Details

    Amphotericin B Powder Usage and Synthesis.

    The molecular composition of Amphotericin B is a macrolide containing 7 pairs of conjugated double bonds as a ligand and a mycosamine deoxyaminohexose as a sugar group, connected by glycosidic bond, due to the structure of an amino group and a carboxylic acid group, so amphoteric substances. Appearance is yellow or orange-yellow powder, odourless or almost odourless, tasteless, moisture-inducing, easy to be destroyed under sunlight failure.

    Gradually decompose above 170℃, unstable at 37℃;. Soluble in dimethyl sulfoxide, slightly soluble in dimethylformamide, very slightly soluble in methanol, insoluble in water, anhydrous ethanol, chloroform or ether. It can form salt in neutral or acidic medium, its water solubility increases but antibacterial activity decreases, its deoxycholate complex is a light yellow powder, can form a colloidal solution in water and can be used for injection.

    Amphotericin B Powder

    Uses and functions of Amphotericin B.

    Amphotericin B is the drug of choice for deep fungal infections with a broad antifungal spectrum. It has inhibitory effect on Cryptococcus, Coccidioides, Candida albicans, Bacillus, etc., and bactericidal effect at high concentration, which is an effective drug for the treatment of deep fungal infections. The main clinical indications are as follows:

    ①Treatment of cryptococcosis, North American budding mycosis, disseminated candidiasis, coccidioidomycosis, histoplasmosis.

    ② Treatment of trichothecosis caused by Rhizopus spp, Ploughshares spp, Endocytosis spp and Frog Faecal Mycobacteria.

    ③Treatment of sporotrichosis caused by Schenkosporium spp.

    ④ Treatment of trichothecosis caused by Aspergillus fumigatus.

    ⑤ Topical preparations for colouring fungal diseases, post-burn skin fungal infections, respiratory tract Candida, Aspergillus or Cryptococcus infections, fungal corneal ulcers

    It has a powerful inhibitory or killing effect on a wide range of fungal infections such as Cryptococcus neoformans, Candida albicans, Histoplasma capsulatum, Dermatophytes, Schenk's spore filamentous fungi, Trichoderma reesei and Coccidioides vulgaris. It is the drug of choice mainly for deep fungal diseases.

    Amphotericin B is a polyene antifungal drug. It binds with sterols on the fungal cell membrane, damaging the membrane permeability, leading to leakage of potassium ions, nucleotides, amino acids, etc. in the fungal cell, destroying the normal metabolism and acting as a bacteriostatic agent.

    Amphotericin B Raw Materials

    Pharmacological Effect of sulfadimoxine.

    Amphotericin B in the cell membrane of the fungus and lipol (fungal plasma membrane sterols) combined to cause changes in the permeability of the cell membrane, resulting in the fungal intracellular components, potassium ions and other components such as amino acids, proteins, etc. leakage to the outside of the membrane, destroying the normal metabolism of the fungus and inhibit the growth of the cell to produce lysis, resulting in the death of the fungal cells.

    Because the cell membrane of bacteria does not contain ergosterol, so this drug does not inhibit or kill bacteria. On the other hand, cholesterol is the main component on the cell membrane of human and animals, and cholesterol has certain affinity with amphotericin B, so it has certain toxicity to human body.

    API Amphotericin B Raw Materials Powder

    Product Method of  Bulk Amphotericin B Powder.

    The strain of Streptomyces nodosus was used as the strain for aeration and deep fermentation in a liquid medium containing carbohydrates and organic nitrogen sources, and amphotericin was extracted from the fermentation broth when a considerable number of potency units had been reached. Amphotericin contains two components, A and B. The A component has little toxicity and weak antifungal effect, and is not used in the clinic, while the B component has a strong effect, and is called Amphotericin B.

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