Calcitriol Vitamin D3 CAS 32222-06-3 Raw Materials Powder

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Calcitriol / Vitamin D3 Powder Usage and Synthesis.

Calcitriol Powder is suitable for treatment of renal dystrophy, parathyroidism, vitamin D-dependent rickets, and vitamin D-resistant rickets in patients with chronic renal failure. 

Calcitriol CAS 32222-06-3, also known as calcitriol, is an active form of vitamin D and a hormone in the body. It plays an important role in regulating the concentration of blood calcium and phosphorus. 

It can improve the blood calcium level by increasing the absorption of calcium ions in the intestine, and increase the release of calcium in the bone to Vitamin D3 Powder is prescribed for renal failure. 

Vitamin D3 Powder is prescribed for renal bone dystrophy in patients with chronic renal failure.

Vitamin D3 Powder is used to treat hypocalcemia, hypoparathyroidism (adults), osteochondrosis, rickets (infants and children), chronic kidney disease, renal bone disease, osteoporosis, and to prevent glucocorticoid-induced osteoporosis.

Application/Function of Calcitriol / Vitamin D3 Powder.

Calcitriol Powder is one of the most important active metabolites of vitamin 1α,25-D3. This metabolite is usually formed in the kidney. The presence of 1α hydroxylase in placenta, monocytes, macrophages, tumor cell The presence of 1α hydroxylase in placenta, monocytes, macrophages, tumor cells, supernatants, lymph nodes from patients with nodular disease and keratinocytes has been shown to produce calcitriol. 

The precursor of calcitriol is 25-hydroxycholecalciferol (alfacalciferol). Dihydroxycholecalciferol has a role in promoting calcium absorption in the small intestine and regulating inorganic salt transport in bone.

Calcitriol Powder, also known as Calcitriol, is the active form of vitamin D and a hormone in the body that plays an important role in regulating blood calcium and phosphorus concentrations by increasing calcium absorption in the intestine and increasing calcium release from bone to raise blood calcium levels. In many cases, calcitriol works by binding to the vitamin D receptor (VDR). For example, the ligand-receptor complex formed by binding the receptor to calcitriol in the cytoplasm of small intestinal epithelial cells is transferred to the nucleus as a transcription factor that promotes the expression of the gene encoding the calcium-binding protein, which increases the active transport of calcium ions by the cell, thereby increasing the level of calcium ion uptake. Calcium ion uptake along with the maintenance of electroneutrality also requires transport of anions, mainly inorganic phosphate ions, so calcitriol also promotes phosphorus uptake. Vitamins. Used for renal osteodystrophy in patients with chronic renal failure.

Calcitriol Powder is a biologically active metabolite of vitamin D3, with stronger effects than D2 and D3. It has a renal hormonal effect, binds to specific receptors in the cytoplasm of the intestinal mucosa and translocates to chromosomes in the nucleus, increasing the transcriptional work of mRNA and promoting the synthesis of proteins that transport calcium in the gastrointestinal tract. It promotes the absorption of calcium in the small intestine, regulates the transport of inorganic salts in bone, corrects low blood calcium, reduces bone and muscle pain, and reduces or normalizes serum alkaline phosphatase and serum parathyroid concentration.

It is indicated for renal osteodystrophy in patients with chronic renal failure, especially in patients requiring long-term hemodialysis; for post-surgical, spontaneous and pseudohypoparathyroidism, vitamin D-dependent rickets, blood phosphate deficiency anti-vitamin D rickets, and postmenopausal and senile osteoporosis.

Production Method of Calcitriol / Vitamin D3 Powder

Vitamin D in the kidney promotes the reabsorption of calcium and phosphorus by the renal tubules, decreases urinary calcium and phosphorus, and increases blood calcium and phosphorus. The effect of vitamin D on renal calcium and phosphorus reabsorption is not a direct effect, but an indirect effect through the inhibition of parathyroid hormone that increases renal tubular phosphorus reabsorption. Calcitriol acts synergistically with parathyroid hormone to promote renal tubular calcium reabsorption. When serum calcium is reduced, active vitamin D formation is accelerated by low calcium stimulation; when serum calcium is increased, active vitamin D formation is slowed by high calcium stimulation. The activation of vitamin D can be affected by liver and kidney dysfunction, which is the reason for the occurrence of hepatic and renal rickets.

The effect of vitamin D on bone inorganic salt metabolism is bidirectional, promoting both the calcification of new bone and the freeing of calcium from bone to keep bone salts updated to maintain calcium homeostasis. Vitamin D acts synergistically with parathyroid hormone and has the effect of promoting osteolysis by osteoclasts and promoting intestinal calcium absorption, resulting in an increase in blood calcium. It is also believed that vitamin D acts first on osteoblasts to cause a gradient in bone resorption concentration, thereby promoting osteoclast formation and osteolysis.

The role of vitamin D in promoting bone formation and bone mineralization has been recognized by most scholars. Calcitriol directly stimulates osteoblasts and induces citric acid in blood and bone to form a complex with calcium, which is transported to new bone and facilitates calcium salt deposition. Vitamin D also acts on osteoblasts, influencing the transcription process of genetic information, promoting protein synthesis and cell differentiation, and accelerating osteogenesis.

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