Chondroitin Sulfate Raw Materials Powder

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Chondroitin Sulfate Powder Usage and Synthesis.

Chondroitin Sulfate Powder (chondroitin sulfate, CS) is an acidic mucopolysaccharide extracted and purified from animal cartilage. Chondroitin Sulfate has long been used as a health food or medicine in the prevention and treatment of coronary heart disease and angina pectoris. CAS 9007-28-7 is used to treat neuralgia, neuropathic migraine, joint pain, arthritis, scapular joint pain, abdominal pain, etc. Chondroitin Sulfate Raw Material is white powder at room temperature, odorless, tasteless, strong water absorption, easy to dissolve in water to form a viscosity solution.

Chondroitinsulfate (CS) is an acidic mucopolysaccharide extracted and purified from animal cartilage tissue. Chondroitin sulfate has different structures such as A, C, D, E, H and K. In nature, chondroitin sulfate is mostly found in animal cartilage, larynx bone, nasal bone (41% in pigs), diaphragm and trachea (36%-39%) in cattle and horses, and other tissues such as leg bones, ligaments, skin, cornea, etc. It is also abundant in fish cartilage. Fish cartilage is rich in content, such as shark bone contains 50% to 60%, the content of connective tissue is very small.

Application/Function of Chondroitin Sulfate Powder.

• 1. Chondroitin sulfate is used as health food or health care drug for a long time to prevent and treat coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases without obvious toxic side effects, and can significantly reduce the morbidity and mortality of patients with coronary heart disease. Long-term clinical application has found that lipids such as fat deposited on the walls of arteries and veins can be effectively removed or reduced, which can significantly reduce plasma cholesterol and thus prevent the formation of atherosclerosis.
• 2．Chondroitin sulfate is used for the treatment of neuralgia, neurological migraine, arthralgia, arthritis and scapular joint pain, pain after laparotomy, etc.
• 3．It is effective in the prevention and treatment of streptomycin-induced hearing impairment and various noise-induced hearing difficulties and tinnitus.
• 4、It has auxiliary therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcer, etc.
• 5. In recent years, it has been reported that the chondroitin in shark cartilage has an anti-tumor effect. In addition, chondroitin sulfate is also used in cosmetics and wound healing agents for trauma.
• 6. Chondroitin sulfate is also used in eye drops.

Pharmacological Effects of Chondroitin Sulfate Powder

Chondroitin sulfate is widely found in human and animal cartilage tissues. Its medicinal preparations mainly contain two isomers, chondroitin sulfate A and chondroitin sulfate C. The content of chondroitin sulfate in cartilage of different species and ages of animals is different.

Its pharmacological effects are expressed as follows:

• 1, chondroitin sulfate can remove lipids and lipoproteins from the blood in the body, remove cholesterol from the blood vessels around the heart, prevent atherosclerosis, and increase the conversion rate of lipids and fatty acids in the cells.
• 2, chondroitin sulfate can effectively prevent and treat coronary heart disease. It has anti-atherosclerosis and anti-atherogenic plaque formation effects on experimental atherosclerosis models; increases atherosclerotic coronary artery branching techniques or collateral circulation, and accelerates the healing, regeneration and repair of myocardial necrosis or degeneration caused by experimental coronary artery sclerosis or embolism.
• 3、It can increase the biosynthesis of messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) of cells as well as the role of promoting cell metabolism.
• 4、Low anticoagulant activity. Chondroitin sulfate has a moderate anticoagulant effect, every lmg of chondroitin sulfate A is equivalent to 0.45U of heparin anticoagulant activity. This anticoagulant activity does not depend on antithrombin III and play a role, it can play anticoagulant activity through the fibrinogen system.
• 5, chondroitin sulfate also has anti-inflammatory, accelerated wound healing and anti-tumor effects.

• (1) for the treatment of coronary heart disease chondroitin sulfate has the effect of clarifying lipids, health food and drugs developed from its raw materials have been used for a long time to prevent coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, clinical application has not been found to have significant toxic side effects, and can significantly reduce the morbidity and mortality of patients with coronary heart disease.
• (2) Improving joint problems Chondroitin sulfate in combination with glucosamine can promote cartilage regeneration and soften bones, and it can effectively improve joint problems as a commonly used drug for treating joint diseases in clinical practice.
• (3) Protect bones Chondroitin sulfate can prevent the increase of bone calcification, prevent bones from becoming hard and brittle, and promote stiff bones to regain flexibility; in addition, chondroitin sulfate can reduce the contour of bones that become hard and brittle and appear dilated to a certain extent, and effectively improve osteophytes.
• (4) Promote the healing of corneal wounds and improve the symptoms of ocular dryness Chondroitin sulfate can improve corneal blood circulation, accelerate metabolism, enhance permeability, promote the absorption of osmotic fluid in the corneal stroma and fiber growth, eliminate inflammation, and have a protective effect on corneal collagen fibers; secondly, chondroitin sulfate can improve the water metabolism of corneal tissue and promote the formation of a breathable water retention film on the surface of the cornea. It promotes the healing of corneal wounds and improves the symptoms of ocular dryness.

It has anticoagulant and antithrombotic effects and is used clinically for the treatment of coronary arteriosclerosis, increased blood lipids and cholesterol, angina pectoris, neuralgia, myocardial ischemia and myocardial infarction. It can also be used to prevent and control hearing disorders caused by streptomycin, as well as migraine, neuralgia, shoulder pain, lumbago, arthritis and hepatitis and skin cosmetics. It is reported that chondroitin sulfate can also effectively improve the repair of cartilage and synovial membrane in joints, maintain the lubrication and elasticity between joint cartilage, and improve joint pain and inflammation.

It also has special effects on tendons, ligaments, diaphragms and cardiovascular diseases. Chondroitin sulfate is also one of the important ingredients in the eye tissue, with the function of promoting corneal water metabolism, improving microcirculation, protecting the cornea and promoting corneal tissue damage repair, as well as forming a protective film on the surface of the cornea to prevent water dissipation, effectively relieving visual fatigue and dry eye symptoms; besides antibacterial and anti-inflammatory, sulfamic acid is also involved in a variety of physiological activities in the eye tissue, promoting metabolism and improving visual In addition to being antibacterial and anti-inflammatory, sulfamic acid is also involved in a variety of physiological activities in eye tissue, promoting metabolism and improving visual fatigue.

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