Posaconazole Powder Raw Material

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Posaconazole Raw Materials Usage and Synthesis

High Purity 99% Posaconazole Raw Material Powder, Supplier Wholesale Posaconazole Raw Powder.Posaconazole Powder China Manufacturer Supply Posaconazole Raw Powder CAS 171228-49-2, MF: C37H42F2N8O4, Posaconazole is effective in preventing invasive fungal infections.

Uses and functions of Posaconazole Powder

1. However, their status as the main prophylactic medication remains unchanged.
2. Posaconazole Raw Materials Echinocandins (caspofungin, anifungin, micafungin) have a narrower antifungal spectrum than triazoles and polyenes.
3. Posaconazole Raw Powder is mainly used for the treatment of Candida infections, which has the advantages of good efficacy and significant safety, but the non-oral dosage form is a major disadvantage.

1. Posaconazole Raw Materials (amphotericin B and its liposomes) are no longer the "gold standard" for the treatment of deep-seated fungal infections, and the decline in the therapeutic status of polyenes is mainly due to their significant adverse effects.
2. Posaconazole Powder is used clinically for the treatment of Aspergillosis, Sjögrenomycosis, Fusarium, and some fluconazole-resistant Candida spp. infections.

Pharmacological Effects of Posaconazole Raw Powder

• Posaconazole exerts its antifungal activity by inhibiting ergosterol biosynthesis.
• Ergosterol is an important component of fungi necessary for maintaining the structural integrity of cell membranes and for the function of some membrane-associated proteins, as well as an essential trace substance in the fungal cell cycle.
• Posaconazole blocks ergosterol synthesis by inhibiting the fungal pigment P45014 alpha-demethylase and causing the accumulation of 14 alpha-methylsterols, among others, and the extent of the blockage is related to the susceptibility of the test strain and the dose of posaconazole.

• Mutant strains of Candida albicans are resistant to itraconazole (ITC), fluconazole (FLC), and voriconazole (VRC) due to mutations in the 14α-demethylase enzyme, but are still sensitive to this product.
• It inhibits sterol biosynthesis in Aspergillus fumigatus and Aspergillus flavus more effectively than ITC.

Production method of Raw Posaconazole Powder

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