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Sulforaphane can cause apoptosis and cell blocking of cancer cells, and at the same time, it can induce II-phase detoxification enzymes in the human body, and at the same time, it can inhibit the production of I-type enzymes, and ultimately, it can discharge harmful components such as carcinogens and free radicals through a variety of enzyme systems, and at the same time, the component will not remain in the human body, and it will have no side effects on the organism. The United States began to study the substance of radish sulfide and its production method from the 1950s.
Uses and functions of Sulforaphane.
Radish sulfide is a multifunctional enzyme inducer that induces the body to produce the type II detoxification enzymes glutathione transferase (GST) and quinone reductase (QR), which are capable of neutralising suspected carcinogens and preventing them from destroying genes in healthy cells, thus acting as an anticancer agent.
Radicicol is only one of many isothiocyanate derivatives with anticancer activity. It is now found that an isothiocyanate compound, either natural or synthetic, directly inhibits both the methylation of CpGDNA in the initiator/5-UTR region of genes and the activity of histone deacetylases (HADC), which have the ability to It can selectively promote histone acetylation and methylation, thus restoring the expression of some genes with important functions that have been abnormally shut down in cancer cells, and exerting their normal functions, so that the malignant proliferation of cancer cells can be controlled, and thus can effectively inhibit the growth of transplanted human tumour cells, including colon cancer, gastric cancer, lung cancer, prostate cancer, hepatocellular carcinoma, colorectal carcinoma, melanoma, and neuroblastoma.
Compared with known DNA methylation inhibitors and natural or synthetic histone deacetylase inhibitors, this series of compounds are unique dual inhibitors with strong anticancer effects, low toxicity and side effects, and stable biological properties, which can be used for the treatment and prevention of various malignant tumours.
Radish thiols have been studied for their anti-tumour properties, their ability to help clear bacteria from the lungs, and their ability to combat gout. It can also be used as an adjunctive treatment for leukaemia.
Pharmacological Effect of Sulforaphane.
It can cause apoptosis and cell blocking of cancer cells, and at the same time, it can induce II-phase detoxification enzymes in the human body, and at the same time, it can inhibit the production of I-type enzymes, and ultimately, it can discharge harmful components such as carcinogens and free radicals through a variety of enzyme systems, and at the same time, the component will not remain in the human body, and it will have no side effects on the organism. The United States began to study the substance of radish sulfide and its production method from the 1950s.
Product Method of Bulk Sulforaphane Liquid.
At present, there are three main methods to synthesise radish sulphur:
1, chemical method synthesis: in 2003 Desai et al. formed a group with isotope labelling within five steps to synthesize radish thiols, yield ~ 10%.
2、Enzymatic method: the precursor of radish sulfur - glucose lycopene was extracted from cruciferous vegetables, and radish sulfur was prepared by hydrolysis.
3, chemical and enzymatic combination: chemical synthesis and enzymatic extraction combined with the method is extracted from the seeds of arugula to get glucose glyceryl trinucleotide, glucose glyceryl trinucleotide as raw material through the selective oxidation reaction to prepare glucose lycopene, and then hydrolysed to get radish sulfur, the process is expected to achieve industrialisation.
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