L - Proline raw material L - Proline Powder 147-85-3

CAS:147-85-3

MF:C5H9NO2

MW:115.13

EINECS:205-702-2

Specification: 99% min L - Proline Powder

Sample:L - Proline Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

L - Proline Powder Usage and Synthesis.

L-Proline (referred to as proline) is one of the eighteen amino acids for protein synthesis in the human body, it is colourless to white crystal or crystalline powder at room temperature, slightly odourless, slightly sweet taste, very soluble in water, insoluble in ethanol, insoluble in ether and n-butanol.

Amino acid is the general name for a class of organic compounds containing amino and carboxyl groups. The presence of amino acids in the human body not only provides important raw materials for the synthesis of proteins, but also provides the material basis for the promotion of growth, normal metabolism, and the maintenance of life.

The main uses of L-proline are as follows:

1, as an amino acid can replenish nutrients, is the raw material of amino acid infusion.

2, It has therapeutic effect on high blood pressure, and is an important intermediate in the synthesis of first-line antihypertensive drugs such as captopril and enalapril.

3, L-Proline and sugar co-heating amino acid-carboxylic acid reaction, can generate a special flavour of the material.

4, As a nutritional supplement, it can improve the resistance of tissues and increase the survival rate of healing tissues.5, It can effectively alleviate the damage of salt stress on the mitochondrial structure of regenerated rice plants.

Uses and functions of L - Proline.

Used in biochemical research, medicinally for malnutrition, protein deficiency, gastrointestinal disorders, scald and post-operative protein supplementation.

Amino acid medicine. One of the ingredients of compound amino acid infusion, used for protein supplementation after malnutrition, protein deficiency, severe gastrointestinal disorders, scald and surgery.

Nutritional supplements. Flavouring agent, and sugar co-heating amino-carbonyl reaction, can generate a special flavour material. It can be used as spice according to GB2760-86.

Used in amino acid injection, compound amino acid infusion, food additives, nutritional supplements and other pharmaceutical raw materials and food additives.

Characteristic of L - Proline.

Colourless crystals, odourless, sweet taste; soluble in water (solubility 162.3g/100ml in 25°C water) and ethanol, insoluble in butanol and ethyl ether, yellow when met with hydrated ninhydrin test solution, glacial acetic acid acid acidification shows red; pI6.3, decomposition point 220-222°C; specific optical rotation [α] 20D-85° (0.5-2.0mg/ml, H2O), [α] 20D-60.4° (0.5-2.0 mg/ml, 5 mol/L HCl).

Production Method of Bulk L - Proline Powder.

There are two methods of L-proline production.

One is the direct fermentation method, using glucose and Pseudomonas aeruginosa variant or Corynebacterium glutamicum wild strain, by microbial fermentation to obtain L-proline;

The second is the chemical synthesis method, using glutamic acid as raw material, esterification with anhydrous ethanol catalysed by sulphuric acid, and adding triethanolamine to free the aminosulphate to obtain glutamic acid-δ-ethyl ester.

Then use the metal reducing agent potassium borohydride to reduce glutamic acid-δ-ethyl ester, get the crude proline, and finally its separation and purification can get the crude proline.