Curcumin raw material Curcumin Powder 458-37-7

CAS:458-37-7

MF:C21H20O6

MW:368.38

EINECS:207-280-5

Specification: 99% min Curcumin Powder

Sample:Curcumin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: orange Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Curcumin Powder Usage and Synthesis.

Kuttan, an Indian scholar, first proposed the anticancer effect of curcumin in 1985. In recent years, curcumin has been found to have an inhibitory effect mechanism on the production, proliferation and metastasis of many kinds of tumour cells.

The National Institute of Oncology of the United States listed it as the 3rd generation of tumour therapeutic drug Curcumin has been used in the treatment of tumours in the United States.

When paired with mitomycin C, it reduces the dosage of mitomycin C. At the same time, it can reduce the nephrotoxicity and myelosuppression produced by the application of mitomycin C alone, and it can improve the effect of mitomycin C in the treatment of breast cancer.

Curcumin has protective effects against various toxic substances such as carbon tetrachloride, aflatoxin B1, acetaminophen, cyclophosphamide-induced hepatic damage in vitro and in vivo, and significantly reduces alkaline phosphatase and r-glutamyl transpeptidase (r-GT) activities in animals with alcoholic liver injury (ALI), preventing the occurrence of experimental fatty liver.

Uses and functions of Curcumin.

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) ac tivity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IB kinase. Inhibits inducible nit ric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nucle ar envelope. Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease (Chem. andEng. News 90(31), 44 (2012)).

Acid-base indicator, pH 7.8 (yellow) to 9.2 (reddish brown). Chromogenic reaction measures beryllium, zirconium and magnesium, borates and reagents.

A natural phenolic, anti-tumour and anti-inflammatory substance with antioxidant properties that induces apoptosis in cancer cells.

Characteristic of Curcumin.

Orange-yellow crystalline powder. With special odour. Melting point 179～182℃. Insoluble in water and ether, soluble in ethanol, glacial acetic acid, propylene glycol. Reddish brown under alkaline condition, light yellow under acidic condition. Forms colour precipitate with magnesium hydroxide, yellowish red.

Forms chelates with metal ions, especially iron ions, resulting in discolouration. About 5mg/kg of iron ions start to affect the pigment, and above 10mg/kg it becomes reddish brown and the colouring ability is reduced, so it is necessary to use appropriate containers.

It is better to use it together with chelating agent sodium hexametaphosphate and acid sodium pyrophosphate. Light resistance, poor resistance to iron ions, heat resistance is better.

Strong adhesion (especially to proteins). There are two active phenol structures in each molecular structure, so it has a certain antioxidant capacity.

Product Method of Bulk Curcumin Powder.

(1) water as a solvent extraction. 70-80 ℃ first 8 times the amount of 1% sodium hydroxide solution leaching 0.175-.036mm turmeric powder 60-75min, filtered filter residue and then leaching twice, the amount of solvent and time can be reduced in order of discretion; combined with the three times the filtrate, add the amount of 0.8% sodium bisulphite solution, after concentration and adjust the PH with hydrochloric acid for 3-4; static stratification and abandon the upper layer Clear liquid, the lower precipitate by filtration of semi-solid curcumin, turmeric oil and turmeric resin mixture; at 70 ℃ in 70% ethanol to dissolve the mixture, while hot and filtered to remove insoluble in ethanol turmeric resin, filtrate and then use petroleum ether extraction to separate the turmeric oil, petroleum ether phase by distillation under reduced pressure recovery of petroleum ether turmeric oil, extracted residual ethanol phase by distillation under reduced pressure curcumin, yields of up to 0.5 percent - 1.5 percent. 1.5%.

(2) Organic solvent extraction.

Curcumin is soluble in ethanol, ether, acetone or methylene chloride and other solvents, can choose one from 0.16-0.32mm turmeric powder leaching curcumin and turmeric oil, after separation and concentration of petroleum ether extraction separation of turmeric oil, extracted residual phase of curcumin by distillation under reduced pressure, the yield is generally 0.55% - 1.5%.

(3) Step-by-step extraction. At 100-105 ℃ turmeric powder steam distillation 4-6h, get turmeric oil, at 80 ℃ with 1% sodium hydroxide solution soaked slag 25min; filtration, filtrate with hydrochloric acid neutralisation acidification, and then filtered to get the curcumin crude, refined to get the finished product.