Pharmaceutical raw material Ascorbyl Palmitate Powder

CAS:11138-66-2

MF:C8H14Cl2N2O2

MW: 241.11496

EINECS:234-394-2

Specification​: 99% min Ascorbyl Palmitate Powder

Sample:Ascorbyl Palmitate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ascorbyl Palmitate Powder Usage and Synthesis.

L-Ascorbyl Palmitate can be used as an antioxidant, as a fat-soluble antioxidant. It is suitable for use in animal and vegetable fats and oils and many types of food. For example, it has significant effect on stabilising soya bean oil, cottonseed oil, palm oil, unsaturated fat and hydrogenated vegetable oil.

L-ascorbyl palmitate is a new type of intelligent food preservative, because of its distinctive effect, it has been commonly used as a fat-soluble antioxidant and nutritional enhancer in vegetable fats and oils or foodstuffs in China.

L-ascorbyl palmitate has a significant antioxidant enhancement compared to L-ascorbic acid; it has a hydrophilic ascorbic acid group and a lipophilic palmitic acid group because of the embedding of the palmitic acid group, which turns it into a high-quality epimer31.

In addition, KageyamaK et al. found that it can significantly inhibit the DNA production of Ehrlichascites tumour cells and dissolve the cytoplasmic unsaturated fatty acids of tumour cells, which makes it a good anti-cancer substance.

It can be predicted that L-ascorbyl palmitate will eventually be active in various industries such as food, skin care products and healthcare products as a flourishing key intelligent preservative.

Uses and functions of Ascorbyl Palmitate.

It can be used in oil-containing foods, edible oils, animal and vegetable oils and high-level cosmetics, and can also be used in a variety of baby food and milk powder, with antioxidant and nutritional enhancement function. It is used as antioxidant whitening agent of VE, with very obvious antioxidant effect in oils and fats and high temperature resistance, suitable for medicine, health products, cosmetics, etc. It is also used as antioxidant agent for baking and frying oils, and the antioxidant effect of lard is better than that of vegetable oils.

As an antioxidant, it can be used in fat-containing foods, instant noodles, edible fats and hydrogenated vegetable oils, with the maximum use amount of 0.2g/kg; it can also be used in infant formula foods, with the maximum use amount of 0.01g/kg (in terms of ascorbic acid in fats and oils).

In addition, it is also used as a food fortifier (the dosage refers to vitamin C).

Mainly as an antioxidant, widely used in food, medicine and other fields.

L-ascorbic acid palmitate can be used as food additives, mainly as a nutritional fortifier and antioxidant preservative, widely used in food and beverage and other fields.

Characteristic of Ascorbyl Palmitate.

L-ascorbic acid palmitate is white or slightly yellow powder, slightly citrus odour, insoluble in water and vegetable oil, easily soluble in ethanol (1 g / 45 ml), MP107 ~ 117 ° C, with a spinning [α] 250 + 21 ~ 24 °, can be stable in dry air.

Product Method of Bulk Ascorbyl Palmitate Powder.

64 g of palmitic acid was placed in a heated dropping funnel and left in a molten state; 200 mI of.

Dichlorosulfoxide into the flask, heating so that its vapour through the conduit into the reaction column equipped with ceramic ring packing, and from the upper part of the column drop added palmitic acid reaction, unreacted dichlorosulfoxide through the reaction of the column on the upper part of the branch pipe condensation back to the flask; palmitic acid drop completed after the reaction 30min, atmospheric distillation to remove a small amount of dichlorosulfoxide, distillation under reduced pressure collection of 150 ~ 152 ° C (2 ~ 3 kPa) fraction of colourless Transparent liquid 58.6g, yield 86% (according to palmitic acid). To a flask was added 26.5 mL.

Dimethylformamide, 2 g of HCl gas was passed at 0 °C, then 9.69 g of crystalline ascorbic acid and 13.3 mL of.

Dichloromethane, at this time the reaction solution was clarified; 15.2 mL, palmitoyl chloride was slowly dropped at 0°C, the reaction was carried out for 18h after the drop was completed, and then the reaction was warmed up to 20°C for 30min.

The reaction product was added to 100mL. ethyl acetate and 200mL. water and washed with stirring for 2h, filtered and washed with water (50mL×3) for 3 times, and dried under vacuum at 50°C for 18h to obtain a white powder of 17.5g, yield 84.3%.