Coenzyme Q10 raw materials Coenzyme Q10 Powder

CAS:303-98-0

MF:C59H90O4

MW:863.34

EINECS:206-147-9

Specification: 99% min Coenzyme Q10 Powder

Sample:Coenzyme Q10 Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

Coenzyme Q10 Powder Usage and Synthesis.

Coenzyme Q10 is a small molecule fat-soluble quinone organic compound widely found in plant and animal cells, with a structure similar to that of vitamin K. It is a powerful antioxidant when used alone or in combination with vitamin E. Coenzyme Q10 is also used as an antioxidant in the body.

It is necessary to drive the body's energy production (ATP) cycle.

Has the function of promoting oxidative phosphorylation reactions and protecting the structural integrity of biological membranes. Different sources of Coenzyme Q have different numbers of side chain isoprenyl units, humans and mammals are 10 isoprenyl units, hence the name Coenzyme Q10.

Coenzyme Q plays an important role in proton translocation and electron transfer in the respiratory chain in vivo. It is an activator of cellular respiration and cellular metabolism, as well as an important antioxidant and non-specific immune enhancer.

Uses of Coenzyme Q10 Powder.

Coenzyme Q10 is used as an endogenous cellular antioxidant; it is an essential component of the ;electron transfer chain.

It is also a coenzyme analogue used as an adjunctive therapy for congestive heart failure, arrhythmias, sinus tachycardia, premature beats, hypertension and cancer; and in the comprehensive treatment of acute and chronic viral hepatitis and subacute hepatic necrosis.

In addition, it is also tried in primary and secondary aldosteronism, cerebrovascular disorders and haemorrhagic shock.

It activates the nutrition of human cells and cellular energy and has the ability to improve human immunity, enhance antioxidant, delay aging and enhance human vitality.

In addition, recent studies have shown that the product also has an anti-tumour effect, clinical for advanced metastatic cancer has a certain degree of efficacy, in the prevention of coronary heart disease, alleviate periodontitis, the treatment of duodenal ulcers and gastric ulcers, to enhance the body's immune function as well as alleviate angina pectoris has a significant effect.

Widely used in pharmaceuticals, cosmetics, food additives and other industries.

Pharmacological Effect of Coenzyme Q10 Powder.

1、It can reduce the weakening of myocardial contractility and the decrease of phosphocreatine and adenosine triphosphate content in acute ischemia, keep the morphology and structure of mitochondria of ischemic cardiomyocytes, and have certain protective effect on ischemic myocardium.

2、It increases cardiac output and reduces peripheral resistance, which is conducive to the treatment of anti-heart failure, and may inhibit the synthesis and secretion of aldosterone and block its effect on renal tubules.

3、When perfusing the isolated ventricular muscle of animals under hypoxic conditions, it can shorten the duration of its action potential and produce ventricular arrhythmia threshold higher than that of control animals.

4、It can make the peripheral vascular resistance decrease, and have anti-aldosterone effect.

5, Coenzyme Q10 has anti-adriamycin cardiotoxic effect and hepatoprotective effect.

Prodct Method of Bulk Coenzyme Q10 Powder.

Alcohol - alkali saponification method of saponification solution preparation take pig heart residue, press dry weighing, according to the dry residue weight plus 300g / L industrial pyrogallic gallic acid, stir, add alcohol - alkali solution (dry residue weight 3-3.5 times the amount of ethanol, 320g / L sodium hydroxide), heating and stirring reflux 25-30min, quickly cooled to room temperature, saponification solution.

Pig heart residue [NaOH] → [pyrogallic gallic acid, ethanol] saponification liquid concentrate preparation take saponification liquid, immediately add its volume 1/10 amount of petroleum ether or 120 gasoline extracted 3-4 times, stirring, stratification, get the extract. Wash to nearly neutral, concentrated to 1/10 of the original volume at 40 ° C or less, cooled, -5 ° C or less static overnight, filtration, to get the concentrate.

Saponification solution [petroleum ether] → extraction solution [<40 ° C] → concentrate coenzyme Q10 refined products preparation of the concentrate over silica gel column chromatography, successively eluted with petroleum ether, 10% ethyl ether - petroleum ether, collect the eluent, recovery of solvents, get yellow oil.

Heating anhydrous ethanol to dissolve, filtration, filtrate static, cooling crystallisation, vacuum drying, coenzyme Q10 refined products. Concentrate [silica gel column, ether-petroleum ether] → eluent [anhydrous ethanol] → coenzyme Q10 refined product.