Pharmaceutical raw material Roxithromycin Powder

CAS:80214-83-1

MF:C41H76N2O15

MW:837.05

EINECS:617-007-5

Specification: 99% min Roxithromycin Powder

Sample:Roxithromycin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Roxithromycin Powder Physical and Chemical properties.

Roxithromycin is a semi-synthetic 14-membered ring macrolide antibiotic. Its mechanism of action is similar to erythromycin, in vivo antibacterial effect is 1-4 times stronger than erythromycin, the role of gram-positive bacteria is slightly worse than erythromycin, the role of Legionella pneumophila is stronger than erythromycin, the anti-microbial effect of Chlamydia pneumoniae, Mycoplasma pneumoniae, ureido ureas, is similar to erythromycin or slightly stronger. Roxithromycin is a semi-synthetic macrolide antibiotic. It can penetrate the bacterial cell membrane and achieve antibacterial effect by inhibiting bacterial protein synthesis.

Uses and functions of Roxithromycin.

Macrolide antibiotics, for erythromycin derivatives, antibacterial spectrum and erythromycin similar, but the role of erythromycin 6 times stronger than erythromycin, high bioavailability.

It is used for respiratory tract infections, such as pneumonia, acute bronchitis, chronic bronchitis acute infections, atypical pneumonia, and genitourinary infections, skin and soft tissue infections, etc., with good therapeutic effect and tolerability, and the adverse effects are smaller than those of erythromycin.

It is a new generation of macrolide antibiotics, mainly used for Gram-positive bacteria, anaerobes, chlamydia and mycoplasma. Its in vitro antibacterial effect is similar to that of erythromycin, and its in vivo effect is 1-4 times stronger than that of erythromycin.

Physiological Effect of Roxithromycin.

Roxithromycin can cross the bacterial cell membrane, in close proximity to the donor ("P" position) and the 50S subunit of the bacterial ribosome into a reversible binding, blocking the transfer of ribonucleic acid binding to the "P" position, but also block the transfer of polypeptide chains from the acceptor ("A" position) to the "P" position, thus inhibiting the synthesis of bacterial proteins, thus playing an antibacterial role. It also blocks the transfer of polypeptide chain from the acceptor site ("A" site) to the "P" site, thus inhibiting bacterial protein synthesis and thus acting as an antibacterial agent. Its characteristic is that it can enter macrophages, alveolar cells and neutrophils more quickly.

In vitro studies have confirmed that roxithromycin has a broad antibacterial spectrum, with antibacterial activity against a variety of streptococci (including Streptococcus A, B, C and Streptococcus pneumoniae, except G and enterococci), Streptococcus pneumoniae, Streptococcus aureus, Staphylococcus aureus (except MRSA), Staphylococcus epidermidis, Legionella pneumophila, Haemophilus ducreyi, Chlamydia trachomatis, Mycoplasma pneumoniae, and oral or vaginal anaerobes almost the same as erythromycin, and Cataplanham. The antibacterial activity is almost the same as that of erythromycin, Catabranococcus is highly sensitive to Roxithromycin, and has inhibitory effect on Campylobacter, Bordetella pertussis, Haemophilus influenzae, Mycobacterium tuberculosis, Mycobacterium diphtheriae, and it has no antibacterial activity on other Gram-negative bacteria.

The in vivo antibacterial activity of Roxithromycin is significantly stronger than that of erythromycin, and it is effective against Chlamydia, Mycoplasma, Ureaplasma urealyticum, Treponema pallidum, and Legionella infections. It has weaker effect on Helicobacter, Gonococcus, Meningococcus, B. pertussis and so on. Certain bacteria are cross-resistant to erythromycin and this product.

Product Method of  Bulk Roxithromycin Powder.

Erythromycin was used as a raw material, and hydroxylamine hydrochloride was reacted in triethylamine and methanol to produce oxime, and then reacted with methoxyethoxymethyl chloride in acetone to obtain Roxithromycin.