Tauroursodeoxycholic acid Raw Materials Tudca Powder

CAS:14605-22-2

MF:C26H45NO6S

MW:499.7

EINECS:1308068-626-2

Specification​: 99% min Tauroursodeoxycholic acid Powder

Sample:Tauroursodeoxycholic acid Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Tudca Powder Usage and Synthesis.

Sodium Ursodeoxycholate is a kind of natural bile acid isolated from bear bile, which is a chemical agent, combined with taurine in the body and exists in the bile, it is a kind of hydrophilic bile acid, and it is a kind of cholesterol stone dissolving agent.

It can reduce the secretion of cholesterol by liver, lower the saturation of cholesterol in bile, promote the secretion of bile acids, increase the solubility of cholesterol in bile, and dissolve cholesterol stones or prevent the formation of stones.

It can increase bile secretion, relax the bile duct sphincter to produce choleretic effect, which is conducive to the discharge of stones. This product cannot dissolve other types of gallstones.

It is suitable for the treatment of cholesterol stones, hyperlipidemia, bile secretion disorders, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis and the prevention of acute rejection and reaction to liver transplantation. The stone dissolving effect of this product is slightly weaker than that of goose deoxycholic acid.

Uses of Tudca.

Taurine ursodeoxycholic acid has antispasmodic, anticonvulsant, anti-inflammatory and cholelithiasis effects, mainly used in the treatment of gallbladder cholesterol stones, primary sclerosing cholangitis, primary biliary cirrhosis and chronic viral hepatitis C, etc.

Preparation of Tudca.

1) The preparation of crude taurine ursodeoxycholic acid was carried out according to the following steps: in the reaction kettle, 4.0KG ursodeoxycholic acid was added, 19KG acetone was added, and 1,650ml of triethylamine was added with stirring, and the jacket refrigeration was turned on to reduce the temperature of the mixed solution to -10℃.

Flow add ethyl chloroformate 1120ml, control the adding speed of ethyl chloroformate, make the reaction liquid temperature is maintained between -5-0 ℃, 30 minutes when added, continue to maintain the temperature of stirring reaction for 40 minutes to produce ursodeoxycholic acid and ethyl chloroformate mixed anhydride, will be the above mixed anhydride reaction liquid through the filter with nitrogen pressure filtration to be equipped with 4.2 KG purified water, 1.4 KG taurine, 1.4 KG sodium hydroxide, 0.4 KG taurine, 0.4 KG sodium hydroxide. 0.4 KG of sodium hydroxide in a 50 liter reactor, and fully stirred the reaction for 3 hours to further produce 4.0 KG of crude taurine ursodeoxycholic acid.

2) taurine ursodeoxycholic acid crude product of refining, according to the following steps: (1) 4.0KG taurine ursodeoxycholic acid into the 50L reaction kettle, add 4KG of water and 580ml of acetone,, heating and stirring until all dissolved; (2) stirring under the cooling to -5-0 ° C, dialysis of crystallization for 30 hours; (3) put the material to the filter in the filtration, pumping, and then icy water (-3-0 ° C) drenched filter cake, and again Pumping dry, get taurine ursodeoxycholic acid 3.3KG (purity 99.6%, HPLC), of which the content of taurine ursodeoxycholic acid is 0.3%, the other largest single heterogeneous content of 0.05% (liquid chromatography determination).

Production process of Bulk Tudca Powder.