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  • Olivetol Raw Materials Powder 500-66-3

    • Olivetol Raw Materials Powder 500-66-3
    • Olivetol Raw Materials Powder 500-66-3 storehouse
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    Product Overview:

    3,5-Dihydroxyalkylbenzene has a wide range of biological activities and is effective against a wide range of pathogenic fungi and bacteria. In recent years, it has been found that in the presence of copper chloride and oxygen, high concentrations of 3,5-dihydroxyalkylbenzene are able to break DNA, so it is used for the inhibition and treatment of human immunodeficiency, cancer and other malignant tumours caused by retroviruses, and the effect is remarkable. 3,5-dihydroxyalkylbenzene can be used to synthesize cannabinoids, which are cannabinoids that are related to the physiological activity of cannabis in the human body. Cannabinoids), cannabinoids is the cannabis in the physiological activity of the human body related to a class of chemical structure of similar substances, the number of more than 60 kinds, can be used for pain, sedative, anti-inflammatory, digestive and anti-hypertensive. The surrogate in this class of compounds is 3,5-dihydroxypentylbenzene (Olivetol)

    Olivetol Raw Materials Powder 500-66-3 Attributes

    Olivetol Raw Materials Powder CAS 500-66-3

    CAS:500-66-3

    MF: C11H16O2

    Olivetol Raw Materials

    MW:180.24

    EINECS:207-908-8

    Specification: 99% min Olivetol Powder

    Sample: Olivetol Soild

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: Clear colorless

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Olivetol Raw Materials Powder 500-66-3 Details

    Olivetol Powder Usage and Synthesis.

    3,5-Dihydroxypentylbenzene is an important pharmaceutical intermediate, first obtained by degrading lichenic acid (also known as D-sonoric acid, pentyl lichen condensate) extracted from the lichen plant, which is mainly used in the laboratory research and development process and in the chemical production process.

    Olivetol Powder

    Uses and functions of Olivetol.

    3,5-Dihydroxypentylbenzene as a precursor for tetrahydrocannabinol-related synthesis.

    Olivetol Raw Materials

    Biological activity of Olivetol Raw.

    Olivetol is a naturally occurring polyphenolic compound found in lichens or produced by some insects.Olivetol competitively inhibits cannabinoid receptors CB1 and CB2, and inhibits the activity of CYP2C19 and CYP2D6, with IC50 and Ki values of 15.3 μM,7.21 μM and 2.71 μM,2.87 μM, respectively.

    Olivetol CAS 500-66-3

    Preparation method of Bulk Olivetol Powder.

    156g of benzene, 900mL of dichloromethane and 146.5g of anhydrous aluminium trichloride were added to a 2L three-necked flask, cooled down to 0-5°C, then 120.5g of n-pentanoyl chloride was added slowly by dropwise addition, keeping the internal temperature at 0-10°C during the dropwise addition. After the dropwise addition, the temperature was raised to 40°C and the reaction was stirred for 2 h. Under the cooling of an ice bath, 500 mL of 1N hydrochloric acid solution was added slowly dropwise, and after the dropwise addition was completed, the solution was partitioned. The aqueous phase was then extracted with 400 mLDCM. The organic phases were combined and concentrated and distilled under reduced pressure to obtain 142 g of valerophenone in 87% yield. In a 1L three-necked flask, 200mL of fuming nitric acid and 200mL of 5% sulfuric acid were prepared as mixed acid within 20℃k, and then the temperature was lowered to within 10℃, and 129.6g of valerophenone was added slowly by dropwise addition, and the internal temperature was controlled to be 0-10℃ during the dropwise addition. After the dropwise addition, the reaction was kept warm for 2h, then the temperature was raised to 50°C, and the reaction was carried out for 5h. After cooling down to 20°C, the reaction solution was poured into crushed ice, the solid was precipitated, filtered, and the filter cake was dissolved with DCM and partitioned, and the organic phase was then concentrated to obtain the crude product. The crude product was dissolved and crystallised by mixing PE and EA and dried to obtain 156.5 g of 3,5-dinitropropentanone in 78% yield and 98.3% purity.

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