Yohimbine Raw Materials Powder

CAS:146-48-5

MF:C21H26N2O3

MW:354.44

EINECS:205-672-0

Specification: 99% min Yohimbine Powder

Sample: Yohimbine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Red Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Yohimbine Powder Usage and Synthesis.

Yohimbine is a natural alkaloid with the molecular formula C12H26N2O3.The drug can be extracted from the bark of the yohimbine tree (CorynantheyohimbeK.Schum.) of the Rubiaceae family, and the root of the Rauvolfia plant of the Rauvolfia genus of the Oleaceae family.

The yohimbine tree is native to Africa and is not produced in this country. Yohimbine can selectively block presynaptic D2 receptors, promote the release of norepinephrine, so that the cavernous nerve endings release more norepinephrine, reduce the venous return of the penis, and facilitate blood-filled erections. When applied in small quantities, it can make the perineum swell, stimulate the spinal erectile centre and play a role in treating erectile dysfunction, and it is an erection inducer that acts on the periphery.

The human body taking yohimbe extract can make the organ blood vessel expansion, increase the blood flow of the organ, increase the formation of nitrous oxide, so as to enhance the sexual function. This is a plant-based treatment for erectile dysfunction is more certain and most used pure plant health food. It can also prevent prostate enlargement and urinary tract infections.

Uses and functions of Yohimbine.

For the treatment of male impotence. It is indicated for the treatment of psychological erectile dysfunction and is less effective in treating organic erectile dysfunction.

Yohimbine was the first prescription drug to be approved by the FDA as a treatment for impotence, and its main action comes from blocking the alpha 2 adrenergic receptor on the central nervous system, which can dilate the blood vessels around the genital organs, allowing complete congestion to solve the problem of incomplete erection, with 34%-43% of the users benefiting from it in a 1987 clinical trial. Yohimbine pure is a white powder, slightly soluble in water, soluble in ethanol, chloroform, hot benzene, slightly soluble in ether.

Yohimbine extracted from the bark of the Yohimbine tree in Ghana can effectively improve male sexual dysfunction, it is reported that in the sun-dried Pansinystalia Yohimba bark, the content of mixed yohimbine alkaloids is as high as 6.1% or more, the main part of which is yohimbine, so the plant extracts have a lot of prospects for development.

Among the dosage forms of yohimbine drugs that have been marketed, there are only two dosage forms: tablets and capsules.

Yohimbine alkaloids have strong pharmacological effects, small dosage, small molecular weight, and become yohimbine hydrochloride after salting with hydrochloric acid, its water solubility is greatly improved, easy to pass through the skin stratum corneum and other characteristics, in line with the made of transdermal therapeutic system.

At the same time, Yohimbine also has the effect of clearing wind-heat, lowering liver fire and eliminating swelling and poison. Yunnan Dai early also have application, in Guizhou is often used as antipyretic, analgesic and treatment of snake bites, Guangxi for anti-inflammatory, antipyretic and treatment of typhoid fever, etc.

Pharmacological Effects of Yohimbine.

Yohimbine selectively blocks presynaptic α2 receptors and promotes the release of norepinephrine. It causes the cavernous nerve endings to release more norepinephrine, reduces penile venous return, and facilitates engorged erection. When applied in small amounts, it can cause swelling of the perineum, stimulate the spinal erectile centre and cause hypersexual function. Yohimbine Hydrochloride can also produce psychological excitation effect and increase sexual desire.

① When applied in small quantities, it acts on the erectile centre of the lumbar spine and induces hypersexual function.

② It has adrenergic blocking effect. Clinical application: Trial for functional impotence due to neurasthenia, also used for secondary impotence due to diabetes and other impotence. Oral each time 0.005 ~ 0.01g, 3 times a day. For severe cases of subcutaneous injection of 2% yohimbine solution 0.5 ~ 1.0ml, 2 ~ 3 times a day, a course of 20 times.

Side effects: there are similar to the local anaesthetic effect of cocaine, occasionally palpitations, insomnia, dizziness and other symptoms. It can be relieved after stopping the drug.

Clinical preparations: yohimbine hydrochloride and commonly used overseas yohimbine-containing compound preparations of yohimbe yuksidol, Xi's yohimbine, Bailuchi yohimbine tablets, Difo yohimbine, Gu's yohimbine, Huo's yohimbine, Knorr yohimbine tablets, yuksite, yohimbine, macrolopin, tolnoctane, and so on. In addition, its similar alkaloids are commonly used as coranine and capitoline.

Caveat of Bulk Yohimbine Powder.

1, pregnant women, breastfeeding women, children, liver and kidney dysfunction, schizophrenia, prostate problems, post-traumatic stress syndrome, cardiovascular disease, blood pressure abnormalities, depression, anxiety, diabetes mellitus patients, do not use (due to potential hazards).

2, Do not use 2 weeks before taking anticoagulant drugs or surgery (may affect blood clotting function).

3, Do not combine with hypertension, diabetes, psychiatric drugs (may affect the effect of drugs, resulting in poor effect or enhance the effect).