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  • Animal raw materials Albendazole Powder

    • Animal raw materials Albendazole Powder
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    Product Overview:

    Albendazole, developed by Skebichem (the predecessor of GlaxoSmithKline), is a broad-spectrum thiabendazole anthelmintic for both human and veterinary use that inhibits the growth and reproduction of worms by inhibiting proteins in the intestinal tract or absorptive cells of the worms, thereby preventing them from ingesting the sugars they depend on for survival, depleting the worms' endogenous glycogen, and inhibiting the enzyme system of fenvalerate reductase, which blocks adenosine triphosphate (ATP) production, thus making it impossible for worms to survive and reproduce, and the worms will ultimately die gradually as a result of energy depletion.

    Animal raw materials Albendazole Powder Attributes

    Animal raw materials Albendazole Powder

    CAS:54965-21-8

    MF:C12H15N3O2S
    Albendazole Raw Materials

    MW:265.33

    EINECS:259-414-7    

    Specification: 99% min Paracetamol Powder

    Sample:Albendazole Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Animal raw materials Albendazole Powder Details

    Albendazole Powder Usage and Synthesis.

    Albendazole has the effect of completely killing the eggs of hookworms and whipworms and partially killing the eggs of roundworms, and can also kill and expel all kinds of nematodes parasitised in the body of animals, and also has obvious killing and expelling effects on tapeworms and cysticerci.

    It is suitable for the treatment of worm (encapsulation) and the nervous system infection caused by the worm in pork (cysticercosis), and is also used for the treatment of hookworm, roundworm, pinworm, trichinella, tapeworm, whipworm and faecal roundworm.

    Albendazole Powder

    Uses and functions of Albendazole.

    1. Albendazole is a highly effective broad-spectrum anthelmintic. It can block the absorption of many kinds of nutrients and glucose by worms, leading to the depletion of the glycogen of the worms, resulting in the inability of the parasites to survive and reproduce. It is used for the treatment of single or mixed sensations caused by roundworms, pinworms, whipworms, hookworms and so on.

    2. It binds microtubule protein and inhibits polymerisation of microtubules.

    3. It is a new drug of high efficiency and broad-spectrum anthelmintic, with remarkable efficacy against liver flake schistosomes, tapeworms, and nematodes of lung and gastrointestinal tract. It is one of the strongest benzimidazole drugs, and it is the first choice for the prevention and treatment of parasitic diseases in livestock and poultry.

    The product is effective against adult and larvae of liver flake trematode of cattle and sheep, and large trematode, and the reduction rate can reach 90-100%. In recent years, it is found that the product also has a strong effect on bovine cysticercus, cysticercus reduction after treatment, the disappearance of foci. In addition, the product can also be used to prevent parasitic infections, so as to promote the growth of sheep to increase wool production, can receive better results.

    4. It is used for the prevention and control of cabbage downy mildew, rice blast, tobacco powdery mildew, anthracnose and so on.

    Albendazole Raw Materials

    Pharmacodynamics of Albendazole.

    Albendazole is a benzimidazole derivative that is rapidly metabolised in vivo to sulfoxide, sulfonol and 2-aminosulfonol. It selectively and irreversibly inhibits glucose uptake in intestinal nematodes, depletes endogenous glycogen, and inhibits the enzyme fumaric acid reductase, preventing the production of adenosine triphosphate and causing death.

    Similar to mebendazole, it causes intracellular transport blockage by inducing cytoplasmic microtubule degeneration in the intestinal cells of the worms and combining with its microtubule proteins, which leads to the accumulation of secretory particles in the Golgi apparatus, gradual dissolution of cytoplasm, and the death of the worms.

    Albendazole has the effect of completely killing the eggs of hookworms, roundworms, pinworms, Trichuris trichiura, tapeworms and cysticercosis whipworms, as well as partially killing the eggs of roundworms.

    Albendazole Raw Powder

    Product method of  Bulk Albendazole Powder.

    (1) 2-acetamido-4-chloronitrobenzene was used as the starting material and reacted with propanethiol to obtain 2-amino-4-propanethio nitrobenzene, which was reduced with palladium carbon to produce 2-amino-4-propanethio aniline. Then, it was cyclised with methyl cyanoformate to obtain propylthiobenzimidazole.

    ( (2) Using o-nitroaniline as the starting material, reacting with sodium thiocyanate to produce 2-nitro-4-thiocyanatobenzenamine, and then reacting with bromopropane to produce 2-nitro-4-propylthioaniline, which was reduced to 2-amino-4-propylthioaniline by sodium sulphide, and then, without separating it, was cyclized with methyl cyanoamino formate to produce propylthiothiobenzimidazole. Total yield 60%.

    (3) to polymyxin as raw material, and sodium sulfur cyanate reaction to cyano-benzimidazole-2-carbamic acid methyl ester, yield 90%. Then carry out the reduction reaction without separation, directly condensed with bromopropane to obtain, yield 94%.

    Alternatively, methyl 5-sulfonyl chloride-benzimidazole-2-carbamate was produced by reacting carbendazim with cyanosulfonic acid in 93% yield. Then it was reduced to methyl 2-mercapto-2-benzimidazole-2-carbamate with iron powder (zinc powder), and then reacted with bromopropane to obtain albendazole.

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