Sulfaguanidine solution Raw Materials Powder

CAS:57-67-0

MF: C7H10N4O2S

MW: 214.24

EINECS: 200-345-9

Specification​: 99% min Sulfaguanidine solution Powder

Sample: Sulfaguanidine solution Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Sulfamethazine Powder Usage and Synthesis.

Sulfadiazine is a low-grade sulfonamide that inhibits bacteria. It is mainly used for the production of sulfadiazine, sulfadimidine, and other high-level sulfonamides.

Sulfonamides, used in bacterial dysentery, enteritis, and as the drug of choice for the treatment of leprosy, are indicated for the treatment of all types of leprosy and can improve clinical symptoms. For general mucosal lesions improve faster, skin lesions improve more slowly, neuropathy is even slower, so the course of treatment is long, easy to produce drug resistance, not easy to cure, in addition, can also be used to treat herpes-like dermatitis, lupus erythematosus, psoriasis, podoconiosis and malaria. The preparation is tablet.

This product is a sulfonamide drug, used for intestinal antibacterial infections, such as bacterial dysentery enteritis, but also for intestinal surgery before the prevention of infection. In the pharmaceutical industry, it is generally used as an important raw material for sulfadiazine drugs such as SM2 and SD.

Uses and functions of Sulfamethazine Raw Materials.

Sulfanilamide and sulfaguanidine used to be the common varieties of sulfonamides, due to the high toxicity, generally not used as the first choice of drugs, now they and acetaminobenzenesulfonyl chloride are only used as intermediates in the production of sulfonamides. Sulfaguanidine, also known as sulfaguanidine, dysentery tablets, the earliest sulfonamides used for intestinal infections, sulfaguanidine molecular structure has a strong basic guanidine group, the dissociation degree is large, the fat solubility is small, although there is a certain amount of intestinal absorption after intake, but not enough to reach the effective blood concentration, so it is not used for systemic infections. But can maintain a higher concentration in the intestine, mostly used for bacterial infections of the digestive tract. Such as gastroenteritis, dysentery, etc. Combined with antimicrobial potentiator methotrexate (TMP) or dimethoate (DVD), its antimicrobial effect is significantly enhanced. Preparation: 1, Sulfanilamide can be produced by melting sulfanilamide and guanidine nitrate in soda ash and condensing under reduced pressure.2, Sulfanilamide can be produced by reacting acetylsulfanilamidochloride with guanidine nitrate in the presence of sodium hydroxide in the mixture of acetone and water.3, Sulfanilamidamide can be produced by taking p-nitrobenzenesulfonyl chloride as raw material, catalytic hydrogenation to produce p-aminobenzenesulfonyl chloride, and then amination, to produce sulfanilamide, and then reacting with guanidine nitrate. Drug interactions: 1, the simultaneous application of urine alkalinising drugs, can enhance the solubility of the product in alkaline urine, so that the excretion increases. 2, sulfaguanidine can not be combined with p-aminobenzoic acid, p-aminobenzoic acid can be substituted for the bacterial uptake of the product, and the two are antagonistic to each other. It should not be combined with local anaesthetics containing p-aminobenzoic acid, such as procaine and bupivacaine.3 For those taking oestrogenic contraceptives, the concomitant prolonged application of sulphaguanidine may lead to a reduction in the reliability of contraception and an increased risk of extra-menstrual haemorrhage.4 An additive effect of photosensitivity may occur when combined with photosensitising medications.5 There is an increased need for vitamin K in those treated with the drug.6 Sulphaguanidine is used to block follicular growth, but it has been shown to be effective in preventing follicular growth.

Sulfaguanidine has been used to block the synthesis of folic acid. It can be used to study its effect on microspore growth and host cell viability.

Pharmacological Sulfamethazine Raw Powder.

Sulfaguanidine is a sulfonamide antibiotic. Sulfaguanidine blocks the synthesis of dihydrofolate by inhibiting dihydropterin synthase. Sulfaguanidine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA; necessary for folate synthesis in bacteria). Sulfaguanidine is an inhibitor of dihydrofolate reductase (DHFR). Sulfaguanidine is active against Gram-positive and Gram-negative bacteria. The mode of resistance is through alteration of dihydropterin synthase or alternative pathways of folate synthesis.

Production method of Sulfamethazine Powder.

Sulfanilamide is obtained by condensation with guanidine nitrate.